Results 71 to 80 of about 258,282 (264)

Preventing railway suicides through level crossing removal: a multiple-arm pre-post study design in Victoria, Australia. [PDF]

open access: yesSoc Psychiatry Psychiatr Epidemiol, 2022
Clapperton A   +4 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Analysis of Failures of Automatic Level Crossing Devices

open access: yesEngineering Proceedings
The safety of automatic level crossing devices (ALDs) is of utmost importance due to the need to ensure safe passage through railway crossings—accidents must not be allowed.
Emiliya Dimitrova   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Modelling of Signal - Level Crossing System

open access: yesAdvances in Electrical and Electronic Engineering, 2006
The author presents an object-oriented model of a railway level-crossing system created for the purpose of functional requirements specification. Unified Modelling Language (UML), version 1.4, which enables specification, visualisation, construction and ...
Daniel Novak
doaj  

Light QCD axion dark matter from double level crossings

open access: yesPhysics Letters B
The even light QCD axion called the ZN axion can both solve the strong CP problem and account for the dark matter (DM). We point out that the single and double level crossings can naturally take place in the mass mixing between the ZN axion and axionlike
Hai-Jun Li   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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