Results 101 to 110 of about 5,497,257 (293)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Level truncation analysis of exact solutions in open string field theory

, 2007
We evaluate vacuum energy density of Schnabl's solution using the level truncation calculation and the total action including interaction terms. The level truncated solution provides vacuum energy density expected both for tachyon vacuum and trivial pure
A. Sen, E. Fuchs, E. Fuchs, I. Ellwood, I. Ellwood, I. Kishimoto, J. Kluson, J. Kluson, J. Kluson, J. Kluson, M. Kiermaier, M. Kiermaier, M. Schnabl, T. Takahashi, Tomohiko Takahashi, Y. Okawa   +15 more
core   +1 more source

Kernel estimation of density level sets

Journal of Multivariate Analysis, 2006
Let $f$ be a multivariate density and $f\_n$ be a kernel estimate of $f$ drawn from the $n$-sample $X\_1,...,X\_n$ of i.i.d. random variables with density $f$. We compute the asymptotic rate of convergence towards 0 of the volume of the symmetric difference between the $t$-level set $\{f\geq t\}$ and its plug-in estimator $\{f\_n\geq t\}$.
openaire   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Phase Separation of a Fast Rotating Boson-Fermion Mixture in the Lowest-Landau-Level Regime

, 2006
By minimizing the coupled mean-field energy functionals, we investigate the ground-state properties of a rotating atomic boson-fermion mixture in a two-dimensional parabolic trap.
A. H. MacDonald, J. R. Abo-Shaeer, Makoto Tsubota, Rina Kanamoto   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Liouvillian Approach to the Integer Quantum Hall Effect Transition

, 2000
We present a novel approach to the localization-delocalization transition in the integer quantum Hall effect. The Hamiltonian projected onto the lowest Landau level can be written in terms of the projected density operators alone. This and the closed set
A.M.M. Pruisken, B. Huckestein, B. Huckestein, B. Huckestein, B. Huckestein, B. Huckestein, B. Mieck, D. Forster, D.-H. Lee, E. Abrahams, E. Fradkin, F. Wegner, F. Wegner, H.P. Wei, H.P. Wei, I.A. Gruzberg, J.T. Chalker, Jairo Sinova, M. Janßen, M. Janßen, M.E. Raikh, S. M. Girvin, S. M. Girvin, S.-R.E. Yang, S.-R.E. Yang, S.M. Girvin, S.M. Girvin, T. Ando, T. Brandes, V. Meden, Y. Huo, Y. Huo, Z. Wang   +32 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Exact Level Densities for the Harmonic Oscillator [PDF]

Physical Review Letters, 2002
The number of levels of a many-fermion system confined by a harmonic-oscillator potential is computed as a function of excitation energy. Because of its exact nature, the formalism accounts for effects of shell structure on the level density. The method is easily extended to a variety of situations as is illustrated with the inclusion of isospin and ...
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source