Results 231 to 240 of about 5,693,533 (296)

Development and simulation of an innovative autonomous knowledge-based smart waste collection system. [PDF]

Sci Rep
Abdallah M, Hosny M.
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Spermidine and Eugenol Modulate Tight Junction and Stemness Markers in Colorectal Cancer Spheroids. [PDF]

Int J Mol Sci
Dilloo S, Hrelia S, Angeloni C, Malaguti M, Dinelli G, Truzzi F.   +5 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

An expectile-based framework for risk-calibrated credible capacity evaluation of virtual power plants under wind and PV forecast uncertainties. [PDF]

Sci Rep
Hua D, Zeng J, Lin Q, Cui S, Liu Y, Liang Y.   +5 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

The First Reported Clinical Outcomes of a Next Generation Five-Layer Foam Dressing for Exudate Management: A Retrospective, Real World, Cohort Analysis From the United States. [PDF]

Int Wound J
Milne C, Tompkin A, Spitzer M, Megginson S, Murdoch JM, McFee K.   +5 more
europepmc   +1 more source

High-Risk Medication Prescriptions Among Older Adults Discharged from the Emergency Department. [PDF]

JAMA Intern Med
Iscoe MS, Sangal RB, Hwang U, Fried TR, Meeker D, Conner TM, Gettel CJ, Follman S, Wright DS, Venkatesh AK.   +9 more
europepmc   +1 more source

Trends in antipsychotic and lithium use in Scandinavian countries from 2010 to 2023: a cross-country drug utilization study. [PDF]

BMC Psychiatry
Hakimi NH, Larsen MD, Bojanic I.
europepmc   +1 more source