Results 111 to 120 of about 2,181,424 (302)
Pared-down landscapes in Antarctica [PDF]
, 1971 The frigid-arid climate that now prevails in ice-free parts of Victoria Land, Antarctica, inhibits glacial erosion. If certain landscapes, more or less remote from the great troughs of outlet glaciers, have been glaciated in the past, as seems very ...
Cotton, C.A., Wilson, A.T.
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Key Scientific Developments Since the IPCC Fourth Assessment Report [PDF]
, 2009 Provides an overview of peer-reviewed research published between July 2006 and June 2009 on fossil fuel emissions; ocean acidification; projected sea level rises; rates of ice and permafrost melting and thawing, and the lasting impacts of global ...
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
, 2011 We study the impact of multi-layered clouds (low-level water and high-level ice clouds) on the thermal emission spectra of Earth-like planets orbiting different types of stars.
A. B. C. Patzer +22 more
core +2 more sources
Region-level labels in ice charts can produce pixel-level segmentation for Sea Ice types
Published at ICLR 2024 Machine Learning for Remote Sensing (ML4RS ...
Patel, Muhammed +5 more
openaire +2 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Marine record of late quaternary glacial-interglacial fluctuations in the Ross Sea and evidence for rapid, episodic sea level change due to marine ice sheet collapse [PDF]
Some of the questions to be addressed by SeaRISE include: (1) what was the configuration of the West Antarctic ice sheet during the last glacial maximum; (2) What is its configuration during a glacial minimum; and (3) has it, or any marine ice sheet ...
Anderson, John B.
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source