Results 91 to 100 of about 2,181,424 (302)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
ISMIP6-based Antarctic projections to 2100: simulations with the BISICLES ice sheet model [PDF]
The CryosphereThe contribution of the Antarctic Ice Sheet is one of the most uncertain components of sea level rise to 2100. Ice sheet models are the primary tool for projecting future sea level contribution from continental ice sheets.
J. F. O'Neill +8 more
doaj +1 more source
Sulfate and MSA in the air and snow on the Greenland Ice Sheet [PDF]
, 1994 Sulfate and methanesulfonic acid (MSA) concentrations in aerosol, surface snow, and snowpit samples have been measured at two sites on the Greenland Ice Sheet.
Davidson, C +3 more
core +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Intensified melting in the Arctic lower troposphere from 1979 to 2023
Advances in Climate Change ResearchIce melting in the atmosphere has far-reaching impacts on cloud microphysical properties, precipitation intensity and type. However, this issue remains largely unexplored in the Arctic. This study adopted the melting level (ML) as a metric to investigate
Yu-Jie Zhou +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Ocean-Ice Shelf Interaction in East Antarctica [PDF]
Oceanography, 2016 Assessments of the Antarctic contribution to future sea level rise have generally focused on ice loss in West Antarctica. This focus was motivated by glaciological and oceanographic observations that showed ocean warming was driving loss of ice mass from
Alessandro Silvano +2 more
doaj
Self-Regulation in High-Level Ice Hockey Players: An Application of the MuSt Theory. [PDF]
Int J Environ Res Public Health, 2021 Ruiz MC +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source