Results 81 to 90 of about 2,181,424 (302)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Damage intensity increases ice mass loss from Thwaites Glacier, Antarctica [PDF]
The CryosphereIce damage, which results from the formation and development of crevasses on glaciers, plays a critical role in ice-shelf stability, grounding-line retreat, and subsequent sea-level rise. Yet, few ice-sheet models explicitly account for ice damage or its
Y. Li +5 more
doaj +1 more source
Modeling Ice Shelf/Ocean Interaction in Antarctica: A Review [PDF]
Oceanography, 2016 The most rapid loss of ice from the Antarctic Ice Sheet is observed where ice streams flow into the ocean and begin to float, forming the great Antarctic ice shelves that surround much of the continent.
Michael S. Dinniman +5 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The long-term sea-level commitment from Antarctica [PDF]
The CryosphereThe evolution of the Antarctic Ice Sheet is of vital importance given the coastal and societal implications of ice loss, with a potential to raise sea level by up to 58 m if it melts entirely.
A. K. Klose +6 more
doaj +1 more source
Sea ice trends in climate models only accurate in runs with biased global warming
, 2017 Observations indicate that the Arctic sea ice cover is rapidly retreating while the Antarctic sea ice cover is steadily expanding. State-of-the-art climate models, by contrast, typically simulate a moderate decrease in both the Arctic and Antarctic sea ...
Eisenman, Ian, Rosenblum, Erica
core +1 more source
EFFECT OF ICE ON LAKES LEVEL [PDF]
Hydrological Sciences Bulletin, 1974 ABSTRACT This report describes an analytical approach to the problem of defining changes in the water levels of two lakes or reservoirs connected by a channel subjected to flow blockages or retardations due to ice. Routing equations for this purpose were derived for Lakes Michigan-Huron and Erie which form a portion of the Great Lakes system ...
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Snow metamorphism: a fractal approach
, 2010 Snow is a porous disordered medium consisting of air and three water phases: ice, vapour and liquid. The ice phase consists of an assemblage of grains, ice matrix, initially arranged over a random load bearing skeleton.
A. D. Frolov +7 more
core +1 more source