Results 61 to 70 of about 2,181,424 (302)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A numerical study on ice failure process and ice-ship interactions by Smoothed Particle Hydrodynamics

International Journal of Naval Architecture and Ocean Engineering, 2019
In this paper, a Smoothed Particle Hydrodynamics (SPH) method is extended to simulate the ice failure process and ice-ship interactions. The softening elastoplastic model integrating Drucker-Prager yield criterion is embedded into the SPH method to ...
Ningbo Zhang, Xing Zheng, Qingwei Ma, Zhenhong Hu   +3 more
doaj   +1 more source

Observational evidence for the convective transport of dust over the central United States [PDF]

, 2016
Bulk aerosol composition and aerosol size distributions measured aboard the DC-8 aircraft during the Deep Convective Clouds and Chemistry Experiment mission in May/June 2012 were used to investigate the transport of mineral dust through nine storms ...
Anderson, B. E., Barth, M. C., Beyersdorf, A. J., Blake, D. R., Chen, G., Corr, C. A., Crosbie, E., Dibb, Jack E., Lawson, R. P., Moore, R. H., Scheuer, Eric M., Schroeder, J. R., Shook, M., Thornhill, K. L., Winstead, E., Ziemba, L. D.   +15 more
core   +3 more sources

Ice-sheet contributions to future sea-level change [PDF]

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2006
Accurate simulation of ice-sheet surface mass balance requires higher spatial resolution than is afforded by typical atmosphere–ocean general circulation models (AOGCMs), owing, in particular, to the need to resolve the narrow and steep margins where the majority of precipitation and ablation occurs.
Gregory, J. M., Huybrechts, Philippe
openaire   +4 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A Modeling Experiment on the Grounding of an Ice Shelf in the Central Arctic Ocean During MIS 6 [PDF]

, 2003
High-resolution chirp sonar subbottom profiles from the Lomonosov Ridge in the central Arctic Ocean, acquired from the Swedish icebreaker Oden in 1996, revealed large-scale erosion of the ridge crest down to depths of 1000 m below present sea level ...
Jakobsson, Martin, Paton, Mark, Siegert, M   +2 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Level ice interactions with multi-legged offshore structures

Инженерно-строительный журнал, 2017
The task of determining the total ice load from drifting level ice floes on 3- and 4-legged structures, widely used in the development of offshore oil & gas fields, was considered in the article.
Valentin Politko, Izmail Kantardgi
doaj   +1 more source