Results 91 to 100 of about 7,556,071 (335)
Levelling the Analysis of Knowledge via Methodological Scepticism [PDF]
, 2013 : In this essay I provide one methodology that yields the level of analysis of an alleged knowledge-claim under investigation via its relations to varying gradations of scepticism. Each proposed knowledge-claim possesses a specified relationship with: (i)
Brant, William A.
core
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
JSES Reviews, Reports, and TechniquesBackground: Medicaid is a means-tested health insurance program for low-income adults (∼30%), children (∼40%), individuals with disabilities (15%) and some elderly patients that are dual Medicare and Medicaid eligible (15%).
Patrick Saunders, MD +6 more
doaj +1 more source
Data Management: The Data Life Cycle [PDF]
, 2012 The scientific site of Kiel provides support for projects with data management requirements due to project size or interdisciplinarity. This infrastructure is the Kiel Data Management Infrastructure (KDMI) and was initially created by SFB574, SFB754 ...
Czerniak, Andreas +4 more
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Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Motions in the Sun at the Photographic Level III. THE EVERSHED EFFECT IN SUNSPOTS OF DIFFERENT SIZES [PDF]
, 1953 T. D. Kinman
openalex +1 more source
The Level I Multiverse is not the same as the Level III Multiverse
, 2017 Anthony Aguirre and Max Tegmark have famously speculated that the Level I Multiverse is the same as the Level III Multiverse. By this, they mean that the parallel universes of the Level III Multiverse can be regarded as similar or identical copies of our own Hubble volume distributed throughout the whole of our (possibly infinite) bubble universe ...
openaire +2 more sources
Sustaining Collection Value: Managing Collection/Item Metadata Relationships [PDF]
, 2008 Many aspects of managing collection/item metadata relationships are critical to sustaining collection value over time. Metadata at the collection-level not only provides context for finding, understanding, and using the items in the collection, but is ...
Dubin, David +4 more
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Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source