Results 91 to 100 of about 1,831,254 (293)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Peroneal muscle influence as a new outlook to the Lauge-Hansen ankle classification: A short report

open access: yesFoot & Ankle Surgery: Techniques, Reports & Cases
Background: The Lauge-Hansen classification system is most commonly used for ankle fractures and dictates treatment options. In this report, a new perspective to the Lauge-Hansen classification system involving the influence of the peroneal muscles for ...
Sarah Taslima, DPM, MS, MBA   +4 more
doaj  

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Surgical management of glenohumeral instability in patients with Ehlers-Danlos syndrome/hypermobility spectrum disorder and their risk of reoperation

open access: yesJSES Reviews, Reports, and Techniques
Background: This study aims to characterize the types of procedures performed on patients previously diagnosed with Ehlers-Danlos syndrome (EDS)/hypermobility spectrum disorder (HSD) and investigate rates of revision surgery following open, arthroscopic,
Julia M. Winschel, MPH   +7 more
doaj  

Modulation of deoxyribonucleic acid polymerase III level during the life cycle of Bacillus subtilis [PDF]

open access: bronze, 1977
Giovanni Ciarrocchi   +4 more
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

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