Results 101 to 110 of about 7,556,071 (335)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Lanthanides and other spectral oddities in a Centauri

, 2010
Context: There is considerable interest in the helium variable a Cen as a bridge between helium-weak and helium-strong CP stars. Aims: We investigate Ce III and other possible lanthanides in the spectrum the of hottest chemically peculiar (CP) star in ...
Adelman, Adelman, Adelman, Asplund, Bagnulo, Biémont, Bohlender, C. R. Cowley, Castelli, Catalano, Cohen, Collado, Cowley, Cowley, Cowley, Hubrig, J. F. González, Kupka, Little, Norris, Norris, Ryabchikova, S. Hubrig, Sadakane, Underhill, Underhill, Wahlgren   +26 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

III.—On the Evidences of Recent Changes of Level in the Mediterranean Coast-Line [PDF]

, 1870
George Maw
openalex   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Spatial transcriptomics reveals unique metabolic profile and key oncogenic regulators of cervical squamous cell carcinoma

Journal of Translational Medicine
Background As a prevalent and deadly malignant tumor, the treatment outcomes for late-stage patients with cervical squamous cell carcinoma (CSCC) are often suboptimal.
Limin Zhou, Jiejie Liu, Peipei Yao, Xing Liu, Fei Chen, Yu Chen, Li Zhou, Chao Shen, You Zhou, Xin Du, Junbo Hu   +10 more
doaj   +1 more source

Quality Improvement Project to Improve Hand Hygiene Compliance in a Level III Neonatal Intensive Care Unit. [PDF]

Children (Basel), 2023
Chitamanni P, Allana A, Hand I.
europepmc   +1 more source

Human Capital and Spatial Heterogeneity in the Iberian Countries’ Regional Growth and Convergence [PDF]

Human capital is believed to be an important conditioning factor in explaining the convergence and the speed of convergence of regional economies, although it is usually excluded from the estimated models due to a lack of consistent data.
Catarina Cardoso, Eric J. Pentecost
core  

Radiative Neutrino Mass in Type III Seesaw Model

, 2009
The simplest type III seesaw model as originally proposed introduces one lepton triplet. It thus contains four active neutrinos, two massive and two massless at tree level. We determine the radiative masses that the latter receive first at two loops. The
A. Zee, Guo-Zhu Ning, Ji-Yuan Liu, M. Gell-Mann, T. Yanagida, Yi Liao   +5 more
core   +1 more source