Results 51 to 60 of about 7,556,071 (335)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Probing Population III Stars in Galaxy IOK-1 at z = 6.96 through He II Emission

, 2011
The He II \lambda 1640 emission line has been suggested as a direct probe of Population III (Pop III) stars at high-redshift, since it can arise from highly energetic ionizing photons associated with hot, metal free stars.
Bessel, Bouwens, Bouwens, Bromm, Casertano, Dawson, de Mello, Ekström, Gnedin, Koekemoer, Komatsu, Kudritzki, Mackey, Madau, Nagao, Nagao, Oesch, Oh, Ouchi, O’Shea, Peng, Prescott, Scannapieco, Scannapieco, Shapley, Smith, Steidel, Steidel, Trenti, Tumlinson, Tumlinson, Tumlinson, Whalen, Yan, Yoshida   +34 more
core   +1 more source

Inverse tri-bimaximal type-III seesaw and lepton flavor violation [PDF]

, 2009
We present a type-III version of inverse seesaw or, equivalently an inverse version of type-III seesaw. Naturally small neutrino masses arise at low-scale from the exchange of neutral fermions transforming as hyperchargeless SU(2) triplets.
D. Ibanez, G. ’t Hooft, J. W. F. Valle, S. Morisi, T. Yanagida   +4 more
core   +2 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Beyond guesswork: how accurate are surgeons at determining the degree of glenoid bone loss in instability surgery?

JSES International
Background: Accurate measurement of glenoid bone loss (GBL) is critical to preoperative planning in cases of recurrent shoulder instability. The concept of critical bone loss has been established with a value of GBL >13.5% being associated with higher ...
Caleb A. LaVigne, MD, Timothy B. Griffith, MD, Zachary C. Hanson, MD, Donald D. Davis, MD, James S. Kercher, MD, Xavier A. Duralde, MD   +5 more
doaj   +1 more source

The exclusive \bar{B} --> \pi e^+ e^- and \bar{B} --> \rho e^+ e^- decays in the two Higgs doublet model with flavor changing neutral currents

, 1998
We calculate the leading logarithmic QCD corrections to the matrix element of the decay b --> d e^+ e^- in the two Higgs doublet model with tree level flavor changing currents (model III).
Ali A., Aliev T. M., Aliev T. M., Atwood D., Atwood D., Buras A. J., Colangelo P., Deshpande N. G., Du D. S., E. O. ILTAN, Greub C., Greub C., Jaus W., Krüger F., Krüger F., Melikhov D., O’Donnell P. J., Paver N., Vainshtein A. I.   +18 more
core   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Calcaneal tuberosity avulsion fractures: A systematic review & meta-analysis of fixation methods

Foot & Ankle Surgery: Techniques, Reports & Cases
Calcaneal tuberosity avulsion fractures, although uncommon, pose significant challenges due to their complexity and high rates of complications. This systematic review evaluates the effectiveness of various surgical fixation techniques for these ...
Karissa Badillo, DPM, Emily Zink, DPM, Jeffrey Manway, DPM, FACFAS   +2 more
doaj   +1 more source

Bounds on charged higgs boson in the 2HDM type III from Tevatron [PDF]

, 2002
We consider the Two Higgs Doublet Model (2HDM) of type III which leads to Flavour Changing Neutral Currents (FCNC) at tree level. In the framework of this model we can use an appropriate form of the Yukawa Lagrangian that makes the type II model limit of
A. Djouadi, A. Mendez, B. Abbot, C. Li, D. Atwood, D. Atwood, D. Atwood, D. Atwood, D. Atwood, D. Atwood, D. Chang, F. Abe, G. Cvetic, J-Alexis Rodriguez, M. Carena, M. Rozo, M. Sher, Marc Sher, R. Martinez, Rodolfo A. Diaz, Rodolfo A. Diaz, S. Glashow, S. Nie, T. Affolder, T.P. Cheng, V. Abazov, W.S. Hou   +26 more
core   +2 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source