Results 51 to 60 of about 1,831,254 (293)

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Midterm outcomes and survivorship of arthroscopic elbow debridement: a comparison of posttraumatic versus primary degenerative osteoarthritis

JSES International, 2022
Background: Arthroscopic debridement is an effective means of surgical management of both degenerative osteoarthritis (DOA) and posttraumatic arthritis (PTA) of the elbow.
Dennis A. DeBernardis, DO, Adam J. Santoro, DO, Nicholas J. Minissale, DO, Jacob M. Kirsch, MD, Quincy T. Cheesman, DO, Frank G. Alberta, MD, Luke S. Austin, MD   +6 more
doaj  

The Level I Multiverse is not the same as the Level III Multiverse

, 2017
Anthony Aguirre and Max Tegmark have famously speculated that the Level I Multiverse is the same as the Level III Multiverse. By this, they mean that the parallel universes of the Level III Multiverse can be regarded as similar or identical copies of our own Hubble volume distributed throughout the whole of our (possibly infinite) bubble universe ...
openaire   +2 more sources

Motions in the Sun at the Photographic Level III. THE EVERSHED EFFECT IN SUNSPOTS OF DIFFERENT SIZES [PDF]

, 1953
T. D. Kinman
openalex   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Infraspinatus or teres minor fatty infiltration does not influence patient outcomes after reverse shoulder arthroplasty with a lateralized glenoid

JSES International, 2021
Background: Previous studies show that reverse shoulder arthroplasty (RSA) may improve forward elevation (FE) but external rotation may remain impaired with substantial teres minor fatty infiltration.
Adam Kwapisz, MD, PhD, Jason P. Rogers, MD, Charles A. Thigpen, PhD, PT, ATC, Ellen Shanley, PT, PhD, OCS, Eric Newton, MSEd, Kyle J. Adams, BS, Ryan Alexander, BS, Richard J. Hawkins, MD, Michael J. Kissenberth, MD, John M. Tokish, MD, Stephan G. Pill, MD   +10 more
doaj  

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Clinical profile and management of a Spanish single-center retrospective cohort of patients with post-chikungunya associated complications

Travel Medicine and Infectious Disease
Background: This study aims to describe post-chikungunya complications chronically developed cases in returning travelers from some epidemic/endemic regions, and the variables that are associated with the progression of acute or subacute cases to the ...
Fernando de la Calle-Prieto, Juan J. Barriga, Marta Arsuaga, Rosa de Miguel, Marta Díaz-Menéndez   +4 more
doaj  

A level III sentinel lymph node in breast cancer

World Journal of Surgical Oncology, 2006
Background For accurate nodal staging, all blue and radioactive lymph nodes should be sampled during the sentinel lymph node biopsy for breast cancer. We report a case of anomalous drainage in which one of the sentinel lymph nodes was unexpectedly found ...
Ghesani Nasrin, Liu Yiyan, Bowers Kim, Kim Steve H   +3 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source