Results 171 to 180 of about 2,635,657 (307)

Segmentation of 3D images of plant tissues at multiple scales using the level set method. [PDF]

open access: yesPlant Methods, 2017
Kiss A   +5 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

An Efficient Algorithm for Level Set Method Preserving Distance Function

open access: yes
The level set method is a popular technique for tracking moving interfaces in several disciplines including computer vision and fluid dynamics. However, despite its high flexibility, the original level set method is limited by two important numerical ...
Thiran, Jean-Philippe   +5 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

A deep Boltzmann machine-driven level set method for heart motion tracking using cine MRI images. [PDF]

open access: yesMed Image Anal, 2018
Wu J   +12 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

A 3-D Level Set Method for Microwave Breast Imaging. [PDF]

open access: yesIEEE Trans Biomed Eng, 2015
Colgan TJ, Hagness SC, Van Veen BD.
europepmc   +1 more source

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