Results 111 to 120 of about 4,533,614 (299)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Chemical Potential Shift in Nd$_{2-x}$Ce$_{x}$CuO$_{4}$: Contrasting Behaviors of the Electron- and Hole-Doped Cuprates

, 2001
We have studied the chemical potential shift in the electron-doped superconductor Nd$_{2-x}$Ce$_{x}$CuO$_{4}$ by precise measurements of core-level photoemission spectra.
A. Fujimori, A. Ino, A. Ino, A.J. Schultz, H. Namatame, H. Takagi, H. Takagi, J. Matsuno, J.M. Tranquada, J.W. Allen, K. Tsutsui, K. Yamada, M. Matsuda, M. Satake, M.Z. Hassan, N. Harima, S. Uchida, S.C. Zhang, S.J. Hagen, Y. Onose, Y. Onose, Y. Taguchi, Y. Tokura   +22 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Assessment and comparison of fatigue in shift workers of a rolling mill and a steel production company [PDF]

طب کار, 2013
Background: High levels of fatigue in the workplaces can lead to reduced productivity, and increase the risk of accidents and injuries. Purpose of this study was to assess and compare the fatigue levels among fixed-dayshift and rotating-shift workers of ...
marziye Abbassinia, farogh Mohammadian, mohammadreza Monazam, somaye MahmoodKhani, mahdi Asghari, navid Ghaemian   +5 more
doaj  

A Fully Unsupervised Texture Segmentation Algorithm

, 2003
This paper presents a fully unsupervised texture segmentation algorithm by using a modified discrete wavelet frames decomposition and a mean shift algorithm.
Fauzi, Mohammad F. A., Lewis, Paul H.
core  

Computational Studies of Light Shift in Raman-Ramsey Interference-Based Atomic Clock

, 2014
Determining light shift in Raman-Ramsey interference is important for the development of atomic frequency standards based on a vapor cell. We have accurately calculated light shift in Raman-Ramsey interference using the density-matrix equations for a ...
Pati, G. S., Shahriar, M. S., Warren, Z., Yu, N.   +3 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Probing a two-level system bath via the frequency shift of an off-resonantly-driven cavity

, 2019
Although the main loss channel of planar microwave superconducting resonators has been identified to be related to an external coupling to a two-level system (TLS) bath, the behavior of such a cavity in the presence of an off-resonant pump has yet to be ...
Briant, Tristan, Capelle, Thibault, Chua, Sheon, Cohadon, Pierre-François, Deleglise, Samuel, Flurin, Emmanuel, Heidmann, Antoine, Ivanov, Edouard, Jacqmin, Thibaut, Palomo, Jose, Rosticher, Michael   +10 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source