Results 91 to 100 of about 9,835,184 (256)

Least squares estimation of a shift in linear processes [PDF]

This paper considers a mean shift with an unknown shift point in a linear process and estimates the unknown shift point (change point) by the method of least squares. Pre-shift and post-shift means are estimated concurrently with the change point.
Bai, Jushan
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Unified MIMO-multicarrier designs: a space–time shift keying approach [PDF]

, 2015
A survey and tutorial is provided on the subject of multiple-input multiple-output (MIMO) multicarrier (MC) systems relying on the space-time shift keying concept.
Sugiura, Shinya, Chen, Sheng, Kadir, Mohammad Ismat, Hanzo, Lajos   +3 more
core   +1 more source

All-microwave Lamb shift engineering for a fixed frequency multi-level superconducting qubit

Communications Physics
It is known that the electromagnetic vacuum is responsible for the Lamb shift, which is a crucial phenomenon in quantum electrodynamics (QED). In circuit QED, the readout or bus resonators that are dispersively coupled can result in a significant Lamb ...
Byoung-moo Ann, Gary A. Steele
doaj   +1 more source

Temporary nurse deployments: a time-series analysis of shift scheduling dynamics and staffing level alignment

International Journal of Nursing Studies Advances
Introduction: Hospitals deploy temporary nurses to bridge staffing gaps. However, evidence remains inconclusive regarding the extent, patterns, and factors driving temporary deployment.
Maryam Ahmadi Shad, MohammadHossein Khorasanizadeh, Sarah N Musy, Franziska Zúñiga, Fatemeh Atoof, Michael Simon   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Effects of Individual Characterestics and Adaptation to Shift Work on Serum Cortisol Levels of Shift Workers

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2008
Introduction: In modern societies, shift work is an essential component of daily life. Since the beginning of research in shift work, researchers have been engaged in the identification of factors predicting adjustment and adaptation to shift work.
M Zare, E Habibi, S Poorabdian, K Abedi
doaj