Results 251 to 260 of about 11,626,435 (297)

Background Levels at Remediation Sites of Natural Resources Table of Contents

, 2005
Background Levels, Remediation Sites
core  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

R-α-Lipoic Acid Attenuates Acetaminophen-Induced Acute Liver Injury by Reducing Oxidative Stress, Inflammation, and Mitochondrial Damage in Mice. [PDF]

Drug Des Devel Ther
Alshehri FS.
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Salivary Cortisol versus Serum Cortisol Levels in Asthmatic Children Treated with Inhaled Corticosteroid Alone or in Combination with Montelukast. [PDF]

J Asthma Allergy
AbdulWahab A, Alsiddig RAA, Al-Naimi A, Maarafiya M, Abushahin A, Hani Y, Singh R, Jerobin J, Bettahi I, Abu-Hasan M.   +9 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Lipidomic predictors of residual insulin production in adults with newly diagnosed type 1 diabetes. [PDF]

Metabolomics
Hostrup PE, Sulek K, Pociot F.
europepmc   +1 more source

Serial C-Reactive Protein Measurements for Prognostication and Antimicrobial Decision-Making in ICU Sepsis Patients: A Retrospective Cohort Study. [PDF]

Int J Gen Med
Al-Dorzi HM, Aleid AM, Alqahtani AA, Alwarafi AA, Alwahbi SF.   +4 more
europepmc   +1 more source

Scottish Seaweeds as Sustainable Sources of Micronutrients: Mineral Composition, Vitamin B₁₂ Content, and Safety Assessment. [PDF]

Food Sci Nutr
Almosa I, Bashir S, Sneddon AA.
europepmc   +1 more source

Genetically predicted N-acetylisoleucine levels mediate the association between PB/PC% lymphocyte and normal pressure hydrocephalus: A mediation Mendelian randomization study. [PDF]

Medicine (Baltimore)
Liu C, Wang J, Yuan Y, Long P, Xiao G, Wang C.   +5 more
europepmc   +1 more source