Results 71 to 80 of about 70,537 (268)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Boosting the Power of Schizophrenia Genetics by Leveraging New Statistical Tools [PDF]

Schizophrenia Bulletin, 2013
Genome-wide association studies (GWAS) have identified a large number of gene variants associated with schizophrenia, but these variants explain only a small portion of the heritability. It is becoming increasingly clear that schizophrenia is influenced by many genes, most of which have effects too small to be identified using traditional GWAS ...
Andreassen, Ole A, Thompson, Wesley K, Dale, Anders M   +2 more
openaire   +4 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Identification of Influential Points in a Linear Regression Model [PDF]

Statistika: Statistics and Economy Journal, 2011
The article deals with the detection and identification of influential points in the linear regression model. Three methods of detection of outliers and leverage points are described. These procedures can also be used for one-sample (independent)datasets.
Jan Grosz
doaj  

Leveraging Statistical Shape Priors in GAN-Based ECG Synthesis

IEEE Access
6 figures, 31 pages, under ...
Nour Neifar, Achraf Ben-Hamadou, Afef Mdhaffar, Mohamed Jmaiel, Bernd Freisleben   +4 more
openaire   +3 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

ANALISIS PENGARUH LEVERAGE, UKURAN PERUSAHAAN DAN PROFITABILITAS TERHADAP KETEPATAN WAKTU PELAPORAN KEUANGAN PADA PERUSAHAAN PERBANKAN

Jurnal Benefita, 2018
This study aims to provide information on what factors make the company not timely in reporting financial statements that will be relevant information for investors in business and economic decision-making.
Viola Syukrina E Janrosl
doaj   +1 more source

Fast approximation of matrix coherence and statistical leverage

, 2011
The statistical leverage scores of a matrix $A$ are the squared row-norms of the matrix containing its (top) left singular vectors and the coherence is the largest leverage score. These quantities are of interest in recently-popular problems such as matrix completion and Nyström-based low-rank matrix approximation as well as in large-scale statistical ...
Drineas, Petros, Magdon-Ismail, Malik, Mahoney, Michael W., Woodruff, David P.   +3 more
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Factors affecting social insurance burden of Vietnam’s small and medium-sized enterprises

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Khoa học Xã hội, 2019
This paper examines factors affecting the social insurance burden of Vietnam’s small and medium-sized enterprises by using the GLS, MLE and Bayesian methods to analyze hypotheses of an SME survey data collected by the General Statistics Office of ...
Huỳnh Thế Nguyễn, Phan Đình Nguyên, Nguyễn Thị Như Ngọc   +2 more
doaj   +1 more source