Results 51 to 60 of about 70,537 (268)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Leveraging Machine Learning for Official Statistics: A Statistical Manifesto
It is important for official statistics production to apply ML with statistical rigor, as it presents both opportunities and challenges. Although machine learning has enjoyed rapid technological advances in recent years, its application does not possess the methodological robustness necessary to produce high quality statistical results.
Puts, Marco, Salgado, David, Daas, Piet
openaire +2 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
ALEVS: Active Learning by Statistical Leverage Sampling
, 2015 Comment: 4 pages, presented as contributed talk in ICML 2015 Active Learning ...
Orhan, Cem, Taştan, Öznur
openaire +3 more sources
Factors Affecting The Integrity Of Property And Real Estate Company Financial Statement
Jurnal AkuntansiCompanies have a responsibility to uphold integrity when disclosing financial reports. This research examines Indonesian Stock Exchange-listed companies in the property and real estate subsector from 2017 to 2021, specifically focusing on the ownership ...
Leny Suzan, Viola Rosselini Rizaldi
doaj +1 more source
Blockchain: Research and Applications, 2021 Service providers usually require detailed statistics in order to improve their services. On the other hand, privacy concerns are intensifying and sensitive data is protected by legislation, such as GDPR (General Data Protection Regulation).
Nikos Fotiou +4 more
doaj +1 more source
Strategies for Leveraging Usage Statistics of Electronic Resources [PDF]
Journal of the Korean Society for information Management, 2005 As the use of electronic information sources becomes increasingly common, the need for understanding their use becomes critical. This paper describes what usage statistics of electronic materials entail, how they can be used for a variety of library decision making, and the process in which the data can be best acquired, processed, analyzed and ...
openaire +1 more source
Fast Statistical Leverage Score Approximation in Kernel Ridge Regression
, 2021 To appear in the 24th International Conference on Artificial Intelligence and Statistics (AISTATS 2021)
Chen, Yifan, Yang, Yun
openaire +2 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Reconstructing SNP allele and genotype frequencies from GWAS summary statistics
Scientific Reports, 2022 The emergence of genome-wide association studies (GWAS) has led to the creation of large repositories of human genetic variation, creating enormous opportunities for genetic research and worldwide collaboration.
Zhiyu Yang +2 more
doaj +1 more source