Results 141 to 150 of about 2,605 (196)
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Current Medicinal Chemistry, 2006
Histamine plays a prominent and diverse role in the pathophysiology of allergic disease and therapeutic intervention is therefore typically focused on blocking the effects of this biogenic amine. A new antihistamine, levocetirizine, is the R-enantiomer of cetirizine dihydrochloride and like its parent compound undergoes minimal hepatic metabolism ...
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Histamine plays a prominent and diverse role in the pathophysiology of allergic disease and therapeutic intervention is therefore typically focused on blocking the effects of this biogenic amine. A new antihistamine, levocetirizine, is the R-enantiomer of cetirizine dihydrochloride and like its parent compound undergoes minimal hepatic metabolism ...
openaire +2 more sources
Levocetirizine in the Treatment of Allergic Diseases
Expert Opinion on Pharmacotherapy, 2009Levocetirizine, the R-enantiomer of cetirizine dihydrochloride, is a new molecule with a potent and selective antihistamine activity.To investigate the evidence that levocetirizine is an effective therapy for allergic disease.Evaluation of published articles in English, or having an English abstract.Clinical trials indicate that levocetirizine is safe ...
Giorgio Walter Canonica +2 more
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Costs Associated With Persistent Allergic Rhinitis Are Reduced by Levocetirizine
Allergy: European Journal of Allergy and Clinical Immunology, 2005 Background: Allergic rhinitis was recently classified by the ARIA guidelines as persistent or intermittent. Levocetivizine was shown to improve symptoms and health-related quality of life of patients with persistent allergic rhinitis in the XPERT™ study,
Jean Bousquet +2 more
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Study of Levocetirizine in Seasonal Allergic Rhinitis
Current Medical Research and Opinion, 2010To evaluate the efficacy of levocetirizine 5 mg once daily in reducing seasonal allergic rhinitis (SAR) symptoms in US adults.This multicenter, randomized, double-blind, placebo-controlled, parallel-group study enrolled adults aged 18 to 65 years with SAR symptoms in the spring in the US.
George Georges, Frank Hampel
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Pharmacokinetic evaluation of levocetirizine
Expert Opinion on Drug Metabolism & Toxicology, 2011There have recently been guidelines developed for the diagnosis and treatment of rhinitis and urticaria. For both conditions, second-generation antihistamines remain as the first-line therapy.The article presents the current pharmacology, chemical properties, pharmacokinetics and metabolism of levocetirizine.
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Levocetirizine: the allergist’s arsenal grows larger
Expert Opinion on Pharmacotherapy, 2004Antihistamines are the cornerstone of treatment for many allergic diseases, such as allergic rhinitis and chronic urticaria. Since the discovery of their beneficial effects in the 1940s, scientists have found molecules with greater selectivity to block specific histamine receptors without some of the detrimental side effects that are seen if ...
R Matthew, Bloebaum, J Andrew, Grant
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Levocetirizine and rupatadine in chronic idiopathic urticaria
International Journal of Dermatology, 2014Abstract Background Chronic idiopathic urticaria ( CIU ) is a common dermatological condition. Its pathogenesis involves mainly histamine and also other mediators, including platelet‐activating factor ( PAF
Madhulika, Johnson +3 more
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The Elusive Structure of Levocetirizine Dihydrochloride Determined by Electron Diffraction
Angewandte Chemie - International Edition, 2023Durga Prasad Karothu +2 more
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