Efficacy and Toxicity Evaluation of Bepotastine Besilate 1.5% Preservative-Free Eye Drops Vs Olopatadine Hydrochloride 0.2% Bak-Preserved Eye Drops in Patients with Allergic Conjunctivitis [PDF]
Clinical Ophthalmology, 2023 María Cecilia Marini,1 Martín Lucas Berra,2 Fernada Girado,3 Paula Alejandra Albera,4 Melina Sol del Papa,5 María Silvia Passerini,5 Alejandro Javier Aguilar6 1Ophthalmology Service, El Cruce-Nestor Kirchner High Complexity Hospital, Buenos Aires ...
Alejandro J Aguilar +1 more
exaly +4 more sources
Comparative inhibitory effects of bepotastine and diphenhydramine on rituximab-induced infusion reactions [PDF]
International Journal of HematologyAbstract Purpose Infusion-related reaction (IRR) is a common adverse event induced by rituximab. Although first-generation histamine 1 receptor antagonists (H1RAs) are commonly used to prevent IRR, evidence on IRR suppression by the second-generation H1RA bepotastine is scarce.
Kazuhiro Yamamoto +2 more
exaly +5 more sources
Pharmacokinetic Modeling of Bepotastine for Determination of Optimal Dosage Regimen in Pediatric Patients with Allergic Rhinitis or Urticaria [PDF]
PharmaceuticsBepotastine, a second-generation antihistamine for allergic rhinitis and urticaria, is widely used in all age groups but lacks appropriate dosing guidelines for pediatric patients, leading to off-label prescriptions. We conducted this study to propose an
Choon Ok Kim +2 more
exaly +4 more sources
Effects of bepotastine, a nonsedating H1-antihistamine, for the treatment of persistent cough and allergic rhinitis: a randomised, double-blind, placebo-controlled trial [PDF]
ERJ Open Research, 2023 Background Empirical therapy with oral histamine-1 receptor antagonists (H1RAs) is often used for patients with suspected upper airway cough syndrome. No placebo-controlled trials with nonsedating H1RAs (nsH1RAs) have evaluated validated cough outcomes ...
Ji-Hyang Lee +5 more
doaj +2 more sources
Old versus new antihistamines: Effects on cognition and psychomotor functions [PDF]
Journal of Family Medicine and Primary Care, 2022 Context: Antihistamines (AHs) are the most widely long-term therapeutic option to manage allergic diseases. This research aimed to study the effects of long-term administration of AHs: on cognitive (memory, mood, attention, sleep and executive function ...
K Sheth Shamil +4 more
doaj +2 more sources
IUCrDataThe crystal structure of bepotastine besylate {systematic name: 1-(3-carboxypropyl)-4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-ium benzenesulfonate, C21H26ClN2O3+·C6H5O3S−) was refined using synchrotron X-ray powder diffraction data, and ...
Jacob K. Salazar +3 more
doaj +2 more sources
Inhibition of RAN attenuates influenza a virus replication and nucleoprotein nuclear export [PDF]
Emerging Microbes and InfectionsNuclear export of the viral ribonucleoprotein (vRNP) is a critical step in the influenza A virus (IAV) life cycle and may be an effective target for the development of anti-IAV drugs.
Lei Cao +14 more
doaj +2 more sources
Indian Journal of Dermatology, 2021 Introduction: Chronic urticaria is common and distressing dermatosis where the search for newer agents with improved effectiveness and tolerability profile is a felt need.
Amrita Sil +7 more
doaj +2 more sources
Chemical Stability Study of H1 Antihistaminic Drugs from the First and the Second Generations, Diphenhydramine, Azelastine and Bepotastine, in Pure APIs and in the Presence of Two Excipients, Citric Acid and Polyvinyl Alcohol [PDF]
Molecules, 2022 The chemical stability of diphenhydramine (DIPH), azelastine (AZE) and bepotastine (BEPO) was examined in solutions and solids. The drugs were subjected to high temperature (70 °C for 35 h) or UV/VIS light (18.902–94.510 kJ/m2) at pH 1–13, to examine ...
Anna Gumieniczek +2 more
doaj +2 more sources
A fluorescence-off based approach for sensitive determination of bepotastine in pharmaceutical and biological matrices considering human safety aspects: sustainability assessment [PDF]
Scientific ReportsA pioneering spectrofluorimetric approach was established to facilitate the precise and environmentally considerate measurement of Bepotastine (BPST), a pharmaceutical compound utilized as a novel anti-allergy treatment.
Badriah Saad Al-Farhan +6 more
doaj +2 more sources