Results 41 to 50 of about 348 (143)
BMC Ophthalmology, 2019 Background To investigate the cytotoxicities of the topical ocular dual-action anti-allergic agents (alcaftadine 0.25%, bepotastine besilate 1.5%, and olopatadine HCL 0.1%) on human corneal epithelial cells (HCECs) and their anti-allergic effects on ...
Sung Il Kim +5 more
doaj +1 more source
Development and Characterization of In Situ Ophthalmic Gel of Bepotastine Besilate
Journal of Drug Delivery and Therapeutics, 2019 The aim of the present work was development and characterization of in-situ Ophthalmic Gel of Bepotastine Besilate to overcome the drawbacks obtained by conventional eye drop. There are two independent variables were used i.e. Carbopol 934 and HPMC K100. Carbopol 934 were used as gelling agent and HPMC K100 were used as bioadhesive polymer.
Ravindranath B Saudagar, Lajri Garge
openaire +1 more source
Optimal Weighted Tests for Replication Studies and the ‘Two‐Trials Rule’ With Multiple Hypotheses
Statistics in Medicine, Volume 45, Issue 15-17, July 2026.ABSTRACT Replication studies for scientific research are an important part of ensuring the reliability and integrity of experimental findings. In the context of clinical trials, the concept of replication has been formalized by the “two‐trials” rule, where two pivotal studies are required to show positive results before a drug can be approved.
David S. Robertson, Thomas Jaki
wiley +1 more source
Involvement of Histamine Released From Mast Cells in Acute Radiation Dermatitis in Mice
Journal of Pharmacological Sciences, 2007 A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and
Saiko Moriyasu +5 more
doaj +1 more source
International Journal of Research and Review, 2022 Background -Ocular allergy is a commonly encountered pathology in clinical practice, which often is under diagnosed and consequently undertreated. These are rarely vision-threatening but can significantly decrease the quality of life for patients. Olopatadine and Bepotastine eyedrop have both antihistaminic and mast cell stabilization action. Their use
Archana V. Manekar, Sharayu Ashok Bhore
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Clinical Otolaryngology, Volume 44, Issue 6, Page 997-1003, November 2019., 2019 Abstract Objectives The aim of the current study was to investigate the effectiveness and clinical feasibility of Biyeom‐go for the treatment of nasal symptoms associated with rhinitis. Design Prospective observational study. Setting This study was conducted at the Woosuk Korean Medicine Medical Center in South Korea.
Mi Ju Son +11 more
wiley +1 more source
Improvement of Dupilumab‐Induced Psoriasiform Eruption Following a Switch to Tralokinumab
JEADV Clinical Practice, Volume 4, Issue 5, Page 1210-1215, December 2025.ABSTRACT Biologic therapies have transformed the management of atopic dermatitis (AD) and prurigo nodularis (PN), yet paradoxical adverse events such as dupilumab‐induced psoriasiform eruption (DPE) are increasingly recognized. We report a 48‐year‐old Japanese man with long‐standing AD and PN who developed scaly, erythematous plaques on the elbows ...
Masato Mizuashi, Yoshinori Sasaki
wiley +1 more source
Dermatology Research and Practice, Volume 2010, Issue 1, 2010., 2010 Effects of olopatadine hydrochloride, a histamine H1 receptor antagonist, on histamine‐induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate. Olopatadine significantly suppressed histamine‐induced wheal, flare, and itch, starting 30 minutes after oral administration.
Takashi Hashimoto +7 more
wiley +1 more source
Usefulness and Safety of Bepotastine Besilate for Pruritic Skin Disorders
Nishi Nihon Hifuka, 2006 ベシル酸ベポタスチンは鎮静効果が比較的弱く，即効性のある薬剤として各種そう痒性皮膚疾患に使用されている。今回，91例のそう痒性皮膚疾患に対してベシル酸ベポタスチンを投与し，その前後でVASスケールを用いてそう痒および眠気の推移について検討した。そう痒に関して投与前の平均VASスコアは60.6から投与1週間後では24.9と有意にスコアの低下がみられ，その効果は8週間投与観察期間中持続した。一方，眠気についてはベシル酸ベポタスチン内服後VASスコアの有意な上昇はみられなかった。また，投与前そう痒が強く，睡眠が障害され，投与前の眠気VASスコアが上昇していた症例では，ベシル酸ベポタスチン投与によるそう痒の改善から有意に眠気のVASスコアの改善がみられた ...
Hidetoshi TAKAHASHI, Hajime IIZUKA
openaire +2 more sources
Advanced Synthesis &Catalysis, Volume 367, Issue 17, September 26, 2025.A mild and versatile strategy enabling the divergent synthesis of α‐fluoroamides and α‐aminoacyl fluorides from 2‐bromo‐2,2‐difluoro alcohols and amines is developed. The reaction shows broad scope and operational simplicity. Mechanistic and density functional theory studies support the formation of a putative gem‐difluoroepoxide intermediate ...
Giulia De Santis +8 more
wiley +1 more source