Results 41 to 50 of about 428 (162)

Identification of SARS‐CoV‐2 Papain‐like Protease (PLpro) Inhibitors Using Combined Computational Approach**

ChemistryOpen, Volume 11, Issue 2, February 2022., 2022
Combined in silico machinery, consisting of long‐ and short‐range molecular interaction methods is capable of filtering large compound databases, yielding a good candidate for a receptor. The advantage of this approach is a fast assessment of a candidate, starting from basic information on both protein and small organic molecule – FASTA sequence and ...
Milan Sencanski, Vladimir Perovic, Jelena Milicevic, Tamara Todorovic, Radivoje Prodanovic, Veljko Veljkovic, Slobodan Paessler, Sanja Glisic   +7 more
wiley   +1 more source

Pharmacokinetics and safety of cenobamate, a novel antiseizure medication, in healthy Japanese, and an ethnic comparison with healthy non‐Japanese

Clinical and Translational Science, Volume 15, Issue 2, Page 490-500, February 2022., 2022
Abstract Cenobamate (XCOPRI and ONTOZRY) is a novel antiseizure medication for the treatment of focal‐onset seizures. Nonetheless, there is limited information on the pharmacokinetics (PKs), safety, and efficacy of cenobamate in Asian people, including Japanese people.
Eunsol Yang, Jung Sunwoo, Ki Young Huh, Yu Kyong Kim, SeungHwan Lee, In‐Jin Jang, Kyung‐Sang Yu   +6 more
wiley   +1 more source

Continuous Flow Decarboxylative Monofluoroalkylation Enabled by Photoredox Catalysis. [PDF]

JACS Au
Herein, we report a scalable and mild strategy for the monofluoroalkylation of a wide array of Giese acceptors via visible-light-mediated photoredox catalysis in continuous flow.
Pasca F, Gelato Y, Andresini M, Serbetci D, Natho P, Romanazzi G, Degennaro L, Colella M, Luisi R.   +8 more
europepmc   +2 more sources

Hydroxyzine‐induced fixed drug eruption and cross‐reaction with oxatomide

, 2023
Journal of Cutaneous Immunology and Allergy, Volume 6, Issue 2, Page 59-60, April 2023.
Mizuki Terada, Shujiro Hayashi, Maki Okamoto, Ken Igawa   +3 more
wiley   +1 more source

Coronavirus in Continuous Flux: From SARS‐CoV to SARS‐CoV‐2

Advanced Science, Volume 7, Issue 20, October 21, 2020., 2020
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has posed a serious threat to public health. Since the outbreak, numerous attempts have been taken to gain insights of the viral structure, the clinical manifestations, and the immune responses caused by SARS‐CoV‐2.
Yetian Dong, Tong Dai, Jun Liu, Long Zhang, Fangfang Zhou   +4 more
wiley   +1 more source

International Coherence of Pediatric Drug Labeling for Drug Safety: Comparison of Approved Labels in Korea and the United States

Clinical Pharmacology &Therapeutics, Volume 107, Issue 3, Page 530-540, March 2020., 2020
The objective of this study was to analyze information on pediatric use in Korean drug product labels and compare it with that in US Food and Drug Administration (FDA) labeling information. Prescription information on pediatric use contained in the commonly used drugs’ product labels approved by Korean government was compared with that approved by the ...
Yun‐Kyoung Song, Nayoung Han, Gilbert J. Burckart, Jung Mi Oh   +3 more
wiley   +1 more source

SIMULTANEOUS ESTIMATION OF BEPOTASTINE BESILATE AND BENZALKONIUM CHLORIDE IN OPHTHALMIC FORMULATION BY RP-HPLC METHOD [PDF]

, 2016
Objective: Development and validation of stability indicating RP-HPLC method for the simultaneous determination of bepotastine besilate (Bepo B) and benzalkonium chloride (BKC) in an ophthalmic dosage form.Methods: A chromatographic separation of the ...
Gupta, Krishna R., Askarka, Sonali S.
core   +1 more source

Observer-masked trial comparing efficacy of topical olopatadine (0.1%), bepotastine (1.5%), and alcaftadine (0.25%) in mild to moderate allergic conjunctivitis

Indian Journal of Ophthalmology, 2019
Purpose: With increasing environmental pollution, the incidence of allergic conjunctivitis is increasing. Newer anti-allergic medications with combined anti-histaminic and mast cell stabilization action can help reducing the use of topical steroids for ...
Lakshey Dudeja, Anuja Janakiraman, Ishani Dudeja, Kaustubh Sane, Manohar Babu   +4 more
doaj   +1 more source

Comparative efficacy of bepotastine besilate 1.5% ophthalmic solution versus olopatadine hydrochloride 0.1% ophthalmic solution in allergic conjunctivitis

Journal of Dr. NTR University of Health Sciences
Aim: To compare the efficacy of topical bepotastine 1.5% and olopatadine 0.1% ophthalmic solutions in relieving ocular signs and symptoms of mild to moderate allergic conjunctivitis.
Sunkara Charitha, Kavitha Mandalapu, Bhavya Kadiri, Undrakonda Vivekanand   +3 more
doaj   +1 more source

High-flow continuous hemodiafiltration successfully decreased blood pregabalin levels in a patient with severe pregabalin intoxication: a case report

Renal Replacement Therapy, 2022
Background Severe pregabalin intoxication may cause serious symptoms, such as coma. Since pregabalin is a small molecule with no protein binding sites and has low volume of distribution, hemodialysis can be effective in eliminating pregabalin from the ...
Takashi Shimazui, Nobuya Kitamura, Kuniyuki Kako, Shinya Iwase, Toshinao Suzuki, Shota Hoshino, Hiromi Futagami, Kazuhiko Kibayashi, Ken-ichiro Nakao   +8 more
doaj   +1 more source