Results 51 to 60 of about 448 (162)

Observer-masked trial comparing efficacy of topical olopatadine (0.1%), bepotastine (1.5%), and alcaftadine (0.25%) in mild to moderate allergic conjunctivitis

Indian Journal of Ophthalmology, 2019
Purpose: With increasing environmental pollution, the incidence of allergic conjunctivitis is increasing. Newer anti-allergic medications with combined anti-histaminic and mast cell stabilization action can help reducing the use of topical steroids for ...
Lakshey Dudeja, Anuja Janakiraman, Ishani Dudeja, Kaustubh Sane, Manohar Babu   +4 more
doaj   +1 more source

Comparative efficacy of bepotastine besilate 1.5% ophthalmic solution versus olopatadine hydrochloride 0.1% ophthalmic solution in allergic conjunctivitis

Journal of Dr. NTR University of Health Sciences
Aim: To compare the efficacy of topical bepotastine 1.5% and olopatadine 0.1% ophthalmic solutions in relieving ocular signs and symptoms of mild to moderate allergic conjunctivitis.
Sunkara Charitha, Kavitha Mandalapu, Bhavya Kadiri, Undrakonda Vivekanand   +3 more
doaj   +1 more source

SIMULTANEOUS ESTIMATION OF BEPOTASTINE BESILATE AND BENZALKONIUM CHLORIDE IN OPHTHALMIC FORMULATION BY RP-HPLC METHOD [PDF]

, 2016
Objective: Development and validation of stability indicating RP-HPLC method for the simultaneous determination of bepotastine besilate (Bepo B) and benzalkonium chloride (BKC) in an ophthalmic dosage form.Methods: A chromatographic separation of the ...
Gupta, Krishna R., Askarka, Sonali S.
core   +1 more source

A cost-effectiveness analysis of second-generation antihistamine 1 receptor blockers and Japanese kampo shoseiryuto for treatment of perennial allergic rhinitis in outpatient settings in Japan

, 2023
<p><strong><span>Background: </span></strong><span>Perennial allergic rhinitis (PAR) is common in Japan. Second-generation antihistamines (SGAs) are used commonly </span><span>for its</span><span ...
Nakagawa, Naoto
core   +1 more source

High-flow continuous hemodiafiltration successfully decreased blood pregabalin levels in a patient with severe pregabalin intoxication: a case report

Renal Replacement Therapy, 2022
Background Severe pregabalin intoxication may cause serious symptoms, such as coma. Since pregabalin is a small molecule with no protein binding sites and has low volume of distribution, hemodialysis can be effective in eliminating pregabalin from the ...
Takashi Shimazui, Nobuya Kitamura, Kuniyuki Kako, Shinya Iwase, Toshinao Suzuki, Shota Hoshino, Hiromi Futagami, Kazuhiko Kibayashi, Ken-ichiro Nakao   +8 more
doaj   +1 more source

A pharmacoeconomic study of olopatadine hydrochloride 0.1% eye drops and bepotastine besilate 1.5% eye drops in the management of allergic conjunctivitis: A cost-effectiveness analysis

Asian Journal of Medical Sciences
Background: Allergic conjunctivitis (AC) affects 10–20% of the Indian population, necessitating cost-effective treatment strategies. Aims and Objectives: We aimed to evaluate the comparison between the pharmacoeconomic profiles of olopatadine ...
Sudipto Chatterjee , Pritama Paul , Abhishek Bhattacharjee , Soumyadeep Mahapatra   +3 more
doaj   +1 more source

Risk of injury associated with the sedative potential of second‐generation antihistamines: A nationwide retrospective cohort study

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2230-2238, July 2026.
Abstract Aim Individual second‐generation antihistamines may possess differential sedative potential due to the variability in central histamine receptor H1 occupancy. This study aimed to evaluate whether the sedative potential of second‐generation antihistamines is associated with the risk of injury during Japan's pollen season. Methods We conducted a
Jumpei Taniguchi, Shotaro Aso, So Sato, Hideo Yasunaga   +3 more
wiley   +1 more source

Comparison of cytotoxicities and anti-allergic effects of topical ocular dual-action anti-allergic agents

BMC Ophthalmology, 2019
Background To investigate the cytotoxicities of the topical ocular dual-action anti-allergic agents (alcaftadine 0.25%, bepotastine besilate 1.5%, and olopatadine HCL 0.1%) on human corneal epithelial cells (HCECs) and their anti-allergic effects on ...
Sung Il Kim, Choul Yong Park, Gladys Fordjuor, Jong Heon Lee, Jong Soo Lee, Ji Eun Lee   +5 more
doaj   +1 more source

Optimal Weighted Tests for Replication Studies and the ‘Two‐Trials Rule’ With Multiple Hypotheses

Statistics in Medicine, Volume 45, Issue 15-17, July 2026.
ABSTRACT Replication studies for scientific research are an important part of ensuring the reliability and integrity of experimental findings. In the context of clinical trials, the concept of replication has been formalized by the “two‐trials” rule, where two pivotal studies are required to show positive results before a drug can be approved.
David S. Robertson, Thomas Jaki
wiley   +1 more source

Involvement of Histamine Released From Mast Cells in Acute Radiation Dermatitis in Mice

Journal of Pharmacological Sciences, 2007
A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and
Saiko Moriyasu, Kouichi Yamamoto, Naoko Kureyama, Keita Okamura, Toshiji Ikeda, Atsushi Yamatodani   +5 more
doaj   +1 more source