Results 41 to 50 of about 3,343,278 (165)
Pallidal versus subthalamic nucleus deep brain stimulation for levodopa‐induced dyskinesia
Annals of Clinical and Translational Neurology, 2020 Objective To compare the efficacy of subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) on reducing levodopa‐induced dyskinesia (LID) in Parkinson’s disease, and to explore the potential underlying mechanisms ...
Shi‐Ying Fan +11 more
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D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia
iScience, 2022 Summary: Degeneration of dopaminergic neurons leads to Parkinson’s disease (PD), characterized by reduced levels of striatal dopamine (DA) and impaired voluntary movements.
Ermanno Florio +7 more
doaj +1 more source
Preclinical models of levodopa-induced dyskinesia
, 2014 L -DOPA-induced dyskinesia (LID) represents one of the major limitations in the current pharmacotherapy of Parkinson's disease (PD) and affects the majority of PD patients.
Francardo, Veronica, +2 more
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Basal ganglia circuits underlying the pathophysiology of levodopa-induced dyskinesia
Frontiers in Neuroanatomy, 2010 Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson’s disease. Dyskinesia are, ultimately, experienced by the vast majority of the patients.
Pedro eBarroso Chinea, Erwan eBezard
doaj +1 more source
Scientific Reports, 2021 Levodopa-induced dyskinesias are abnormal involuntary movements experienced by the majority of persons with Parkinson’s disease (PwP) at some point over the course of the disease.
Murtadha D. Hssayeni +3 more
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The serotonergic system in levodopa-induced dyskinesia
, 2014 An increasing body of experimental evidence suggests that serotonergic neurons play a major role in the production of levodopa-derived dopamine when dopaminergic neurons have degenerated, and that unregulated release of dopamine from serotonergic neurons
TRONCI, ELISABETTA +5 more
core +1 more source
A Subpopulation of Striatal Neurons Mediates Levodopa-Induced Dyskinesia [PDF]
, 2018 Parkinson's disease is characterized by the progressive loss of midbrain dopamine neurons. Dopamine replacement therapy with levodopa alleviates parkinsonian motor symptoms but is complicated by the development of involuntary movements, termed levodopa ...
Anatol C. Kreitzer +15 more
core +1 more source
Doxycycline to treat levodopa-induced dyskinesias in Parkinson's disease: a preliminary study
Arquivos de Neuro-Psiquiatria, 2023 Background Levodopa-induced dyskinesia (LID) is a common motor complication of levodopa therapy in patients with Parkinson's disease (PD). Doxycycline is a widely used and inexpensive tetracycline with anti-inflammatory properties.
Bruno Lopes Santos-Lobato +5 more
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Intestinal Decontamination Therapy for Dyskinesia and Motor Fluctuations in Parkinson's Disease
Frontiers in Neurology, 2021 Parkinson's disease is neurodegenerative disorder with an initial robust response to levodopa. As the disease progresses, patients frequently develop dyskinesia and motor fluctuations, which are sometimes resistant to pharmacological therapy.
José Fidel Baizabal-Carvallo +2 more
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Resting tremor in Parkinson disease: a negative predictor of levodopa-induced dyskinesia
, 2011 It is unclear whether patients with different clinical subtypes of Parkinson disease (PD) differ in their risk of developing levodopa-induced dyskinesia (LID) and whether resting tremor is negatively correlated with this ...
Kipfer, Stefan +4 more
core +1 more source