Results 21 to 30 of about 60,411 (353)
Identification of TH Variants in Chinese Dopa-Responsive Dystonia Patients and Long-Term Outcomes
Frontiers in Neurology, 2021 Background: Dopa-responsive dystonia (DRD) is a movement disorder that is highly clinically and genetically heterogeneous. Our study summarizes clinical characteristics and long-term outcomes in patients with dopa-responsive dystonia with the aim of ...
Xin-yao Li +7 more
doaj +1 more source
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Science, 2019 The dope on l-dopa metabolism The efficacy of l-dopa treatment for Parkinson's disease is hugely variable between individuals, depending on the composition of their microbiota.
Vayu Maini Rekdal +4 more
semanticscholar +1 more source
Experience in using levodopa-benserazide
Неврология, нейропсихиатрия, психосоматика, 2015 Levodopa remains the most effective drug for the treatment of Parkinson's disease. The paper considers the mechanism of action, recommended levodopa doses, the time of therapy initiation, and risk factors for motor complications.
Elena Anatolyevna Katunina +3 more
doaj +1 more source
Nature Communications, 2019 Human gut microbiota senses its environment and responds by releasing metabolites, some of which are key regulators of human health and disease. In this study, we characterize gut-associated bacteria in their ability to decarboxylate levodopa to dopamine
Sebastiaan P. van Kessel +6 more
semanticscholar +1 more source
Effects of levodopa on gut bacterial antibiotic resistance in Parkinson’s disease rat
Frontiers in Aging Neuroscience, 2023 The second most prevalent neurodegenerative ailment, Parkinson’s disease (PD), is characterized by both motor and non-motor symptoms. Levodopa is the backbone of treatment for PD at the moment.
Shuo Sheng +6 more
doaj +1 more source
Vision-Based Assessment of Parkinsonism and Levodopa-Induced Dyskinesia with Deep Learning Pose Estimation [PDF]
Journal of NeuroEngineering and Rehabilitation (2018) 15:97, 2017 Objective: To apply deep learning pose estimation algorithms for vision-based assessment of parkinsonism and levodopa-induced dyskinesia (LID). Methods: Nine participants with Parkinson's disease (PD) and LID completed a levodopa infusion protocol, where symptoms were assessed at regular intervals using the Unified Dyskinesia Rating Scale (UDysRS) and ...
arxiv +1 more source
ADMET and DMPK, 2022 Levodopa is routinely co-administered with carbidopa in the management of Parkinson’s disease. Although the aforementioned combination therapy is effective, there may be fluctuating plasma levels of levodopa after oral administration.
Emelia Priscilla Imbeah +8 more
doaj +1 more source
Randomized Delayed‐Start Trial of Levodopa in Parkinson's Disease
New England Journal of Medicine, 2019 BACKGROUND Levodopa is the main treatment for symptoms of Parkinson's disease. Determining whether levodopa also has a disease‐modifying effect could provide guidance as to when in the course of the disease the treatment with this drug should be ...
C. V. Verschuur +13 more
semanticscholar +1 more source
Impact of initial treatment on future symptoms and quality of life in Parkinson's disease
Chinese Journal of Contemporary Neurology and Neurosurgery, 2022 Objective To explore the effects of different initial drug treatment on motor symptoms, cognitive function and quality of life in patients with Parkinson's disease (PD).
LI Yu⁃wang +5 more
doaj +1 more source
Levodopa responsive gait dynamics in OFF- and ONOFF-state freezing of gait in Parkinson’s disease
Clinical Parkinsonism & Related Disorders, 2023 Background: In people with Parkinson’s disease (PwPD), Freezing of Gait (FOG) episodes can be levodopa responsive (OFF-FOG) or levodopa unresponsive (ONOFF-FOG).
Tuhin Virmani +3 more
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