Results 341 to 350 of about 95,577 (390)
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JAMA: The Journal of the American Medical Association, 1972
To the Editor.— Entitled "Psychiatric Side Effects of Levodopa in Man,"1Frederick Goodwin's article inThe Journaldescribed visual hallucinations among the adverse side effects in Parkinsonian patients treated with levodopa. Prior to this, others2-6described psychosis as an occasional adverse side effect of therapy with levodopa.
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To the Editor.— Entitled "Psychiatric Side Effects of Levodopa in Man,"1Frederick Goodwin's article inThe Journaldescribed visual hallucinations among the adverse side effects in Parkinsonian patients treated with levodopa. Prior to this, others2-6described psychosis as an occasional adverse side effect of therapy with levodopa.
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Cardiovascular Effects of Levodopa
JAMA: The Journal of the American Medical Association, 1971The patient with Parkinson's disease under treatment with levodopa may be subject to potentially hazardous cardiovascular effects. The most serious side effect of levodopa in patients is ventricular arrhythmia which is unlikely to occur in a subject with normal heart but a risk in patients with myocardial irritability or ischemia.
Thomas L. Whitsett +1 more
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Clinical Neuropharmacology, 2012
To compare bioavailability and pharmacokinetics of single doses of 3 different levodopa formulations given orally in healthy volunteers. Two marketed formulations, standard levodopa/carbidopa, 100/25 mg (LC-100), and dispersible levodopa/benserazide, 100/25 mg (LB-100), were used as reference formulations for a newly developed dispersible microtablet ...
Mats Ehrnebo +7 more
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To compare bioavailability and pharmacokinetics of single doses of 3 different levodopa formulations given orally in healthy volunteers. Two marketed formulations, standard levodopa/carbidopa, 100/25 mg (LC-100), and dispersible levodopa/benserazide, 100/25 mg (LB-100), were used as reference formulations for a newly developed dispersible microtablet ...
Mats Ehrnebo +7 more
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Movement Disorders, 2007
AbstractLevodopa‐induced dyskinesias (LID) are common and difficult to treat. This review focuses on three issues related to LID: clinical features, classification and rating, pathophysiology and pathogenesis, and management. The three primary clinical syndromes are OFF‐period dystonia, peak‐dose dyskinesia, and diphasic dyskinesia. Several other forms
FABBRINI, Giovanni +4 more
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AbstractLevodopa‐induced dyskinesias (LID) are common and difficult to treat. This review focuses on three issues related to LID: clinical features, classification and rating, pathophysiology and pathogenesis, and management. The three primary clinical syndromes are OFF‐period dystonia, peak‐dose dyskinesia, and diphasic dyskinesia. Several other forms
FABBRINI, Giovanni +4 more
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Annals of Internal Medicine, 1980
Excerpt To the editor: The letter of Lejonc and colleagues (1) in the November 1979 issue on a patient who developed flushing and palpitations and, later, elevated pulse rate and blood pressure as ...
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Excerpt To the editor: The letter of Lejonc and colleagues (1) in the November 1979 issue on a patient who developed flushing and palpitations and, later, elevated pulse rate and blood pressure as ...
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The Effect of Levodopa or Levodopa-Carbidopa (Sinemet) on Fracture Healing
Journal of Orthopaedic Trauma, 2006Levodopa (L-dopa) and L-dopa/carbidopa were evaluated to determine their effectiveness in the stimulation of bone healing of fractures at risk for nonunions.Forty-two retired breeder female Sprague-Dawley rats were divided into 2 experimental groups and 1 control. Thirty-six rats were evaluated for results. The right femur of each rat was fractured and
Gregory A. Tayrose +4 more
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Determination of Purity of Levodopa and Levodopa Products by GLC
Journal of Pharmaceutical Sciences, 1974A simple GLC procedure for the detection and quanti-tation of possible impurities in levodopa raw material and commercial dosage forms is presented. The sample is reacted with N,O-bis(trimethylsilyl)acetamide in acetonitrile at ambient temperature for 30 min, and the silyl derivatives are separated on a methyl silicone column under isothermal ...
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The effect of an increased ratio of carbidopa to levodopa on the pharmacokinetics of levodopa
Acta Neurologica Scandinavica, 2009A randomized, cross-over study was designed to compare the effects of an increased ratio (from 1:10 to 1:4) of carbidopa to levodopa on the fate of levodopa and carbidopa in 11 healthy subjects. Four combinations of carbidopa/levodopa (10 mg/100 mg, 25 mg/100 mg, 25 mg/250 mg, 62.5/250 mg) were used.
A Vuorela +4 more
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Neurology, 1996
Shortly after the introduction of high-dosage levodopa for the treatment of Parkinson's disease (PD), adverse motor effects of dyskinesias and clinical fluctuations ("wearing-off" and "on-off" phenomena) were seen [see [1] for historical review]. This soon led to the suggestion [2] that the introduction of levodopa for the treatment of PD should be ...
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Shortly after the introduction of high-dosage levodopa for the treatment of Parkinson's disease (PD), adverse motor effects of dyskinesias and clinical fluctuations ("wearing-off" and "on-off" phenomena) were seen [see [1] for historical review]. This soon led to the suggestion [2] that the introduction of levodopa for the treatment of PD should be ...
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Comparison of Levodopa with Carbidopa, and Levodopa with Domperidone in Parkinsonʼs Disease
Clinical Neuropharmacology, 1986In a comparison of the effects of domperidone and carbidopa during levodopa treatment, 20 patients with idiopathic Parkinson's disease were treated with fixed dose regimens of either levodopa 500 mg-domperidone 20 mg or levodopa 100 mg-carbidopa 25 mg; each for 8 weeks.
J D Parkes, P N Malcolm, N Langdon
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