Results 351 to 360 of about 95,577 (390)
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Neurology, 1998
Whether a drug such as levodopa, which is prescribed for long periods, may be toxic is a legitimate and even indispensable question. The problem is no different from that posed by other drugs-such as calcium antagonists, antihypertensives, or hormones-normally prescribed for chronic diseases. What, however, is meant in this context by "toxic" (from the
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Whether a drug such as levodopa, which is prescribed for long periods, may be toxic is a legitimate and even indispensable question. The problem is no different from that posed by other drugs-such as calcium antagonists, antihypertensives, or hormones-normally prescribed for chronic diseases. What, however, is meant in this context by "toxic" (from the
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Pharmacokinetics and pharmacodynamics of levodopa
Movement Disorders, 2008The pharmacokinetics and pharmacodynamics of levodopa are dominated by two features: the short plasma half-life of the drug and the portion of the antiparkinsonian response that parallels the plasma levodopa levels, the so-called short-duration response. These features are the basis of motor fluctuations that complicate long-term therapy with levodopa.
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Levodopa, Fertility, and Longevity
Science, 1977High concentrations of the dopaminergic drug levodopa (L-dopa, L-3,4-dihydroxyphenylalanine) administered to mice in their diet affected fertility to a moderate degree and prolonged the mean life-span by a maximum of 50 percent.
George C. Cotzias +4 more
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The Lancet, 1970
Abstract Five patients with acute hepatic failure in coma or stupor were given drugs affecting neurotransmission. Levodopa (L-dopa) produced in three patients a striking though temporary improvement in the level of consciousness together with striking improvement in the previously abnormal electroencephalographic (E.E.G.) recordings.
J. D. Parkes +2 more
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Abstract Five patients with acute hepatic failure in coma or stupor were given drugs affecting neurotransmission. Levodopa (L-dopa) produced in three patients a striking though temporary improvement in the level of consciousness together with striking improvement in the previously abnormal electroencephalographic (E.E.G.) recordings.
J. D. Parkes +2 more
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JAMA: The Journal of the American Medical Association, 1975
To the Editor.— A variety of animal 1,2 and human 3 experiments have suggested that neural transmitters may mediate some of the symptoms of alcohol intoxication and withdrawal. Also, there is evidence to suggest that a dopamine agonist (apomorphine) reduces craving for alcohol in human alcoholics 4 and ethanol stimulation in mice.
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To the Editor.— A variety of animal 1,2 and human 3 experiments have suggested that neural transmitters may mediate some of the symptoms of alcohol intoxication and withdrawal. Also, there is evidence to suggest that a dopamine agonist (apomorphine) reduces craving for alcohol in human alcoholics 4 and ethanol stimulation in mice.
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Levodopa challenge test: indications, protocol, and guide
Journal of Neurology, 2020Gerard Saranza, A. Lang
semanticscholar +1 more source