Maladaptive plasticity in levodopa-induced dyskinesias and tardive dyskinesias: old and new insights on the effects of dopamine receptor pharmacology. [PDF]
, 2014 Maladaptive plasticity can be defined as behavioral loss or even development of disease symptoms resulting from aberrant plasticity changes in the human brain.
Ahmed +58 more
core +2 more sources
Levodopa responsive gait dynamics in OFF- and ONOFF-state freezing of gait in Parkinson’s disease
Clinical Parkinsonism & Related Disorders, 2023 Background: In people with Parkinson’s disease (PwPD), Freezing of Gait (FOG) episodes can be levodopa responsive (OFF-FOG) or levodopa unresponsive (ONOFF-FOG).
Tuhin Virmani +3 more
doaj
Magnetic resonance imaging-guided phase 1 trial of putaminal AADC gene therapy for Parkinson's disease. [PDF]
, 2019 ObjectiveTo understand the safety, putaminal coverage, and enzyme expression of adeno-associated viral vector serotype-2 encoding the complementary DNA for the enzyme, aromatic L-amino acid decarboxylase (VY-AADC01), delivered using novel intraoperative ...
Bankiewicz, Krystof S +10 more
core +1 more source
EuroInf 2: Subthalamic stimulation, apomorphine, and levodopa infusion in Parkinson's disease
Movement Disorders, 2019 Real‐life observational report of clinical efficacy of bilateral subthalamic stimulation (STN‐DBS), apomorphine (APO), and intrajejunal levodopa infusion (IJLI) on quality of life, motor, and nonmotor symptoms (NMS) in Parkinson's disease (PD).
H. Dafsari +23 more
semanticscholar +1 more source
Comparative adsorption of levodopa from aqueous solution on different activated carbons [PDF]
, 2009 Adsorption on activated carbon has been successfully used in wastewater and drinking water treatment plants for the removal of various pollutants. Among them, pharmaceutical compounds have become a growing issue. The present study has focused on levodopa
Delmas, Henri +4 more
core +1 more source
Use of apomorphine in Parkinsonian patients with neuropsychiatric complications to oral treatment [PDF]
, 1997 Neuropsychiatric side effects often complicate anti-Parkinsonian therapy and pose a significant problem in the optimal management of idiopathic Parkinson's disease.
Abbott, R.J. +6 more
core +2 more sources
Effects of levodopa on gut bacterial antibiotic resistance in Parkinson’s disease rat
Frontiers in Aging Neuroscience, 2023 The second most prevalent neurodegenerative ailment, Parkinson’s disease (PD), is characterized by both motor and non-motor symptoms. Levodopa is the backbone of treatment for PD at the moment.
Shuo Sheng +6 more
doaj +1 more source
A Wearable Sweat Band for Noninvasive Levodopa Monitoring.
Nano letters (Print), 2019 Levodopa is the standard medication clinically prescribed to patients afflicted with Parkinson's disease. In particular, the monitoring and optimization of levodopa dosage is critical to mitigate the onset of undesired fluctuations in the patients ...
Li-Chia Tai +12 more
semanticscholar +1 more source
Serotonin system implication in L-DOPA-induced dyskinesia: from animal models to clinical investigations [PDF]
, 2014 In the recent years, the serotonin system has emerged as a key player in the induction of l-DOPA-induced dyskinesia (LID) in animal models of Parkinson's disease. In fact, serotonin neurons possess the enzymatic machinery able to convert exogenous l-DOPA
CARTA, MANOLO, TRONCI, ELISABETTA
core +1 more source
Impact of initial treatment on future symptoms and quality of life in Parkinson's disease
Chinese Journal of Contemporary Neurology and Neurosurgery, 2022 Objective To explore the effects of different initial drug treatment on motor symptoms, cognitive function and quality of life in patients with Parkinson's disease (PD).
LI Yu⁃wang +5 more
doaj +1 more source