Results 31 to 40 of about 69,036 (281)

A regression analytical model of serum levodopa metabolic profile in Parkinson's disease

Heliyon
Although levodopa and its metabolites in blood have been investigated in parkinsonian disorders for biomarkers, medication effects of levodopa-associated drugs remain unclear. In this study, we investigated levodopa associated metabolites to characterize
Akiko Chukyo, Osamu Komori, Motoki Fujimaki, Naoko Kaga, Hikari Taka, Yuanzhe Li, Shin-Ichi Ueno, Haruka Takeshige-Amano, Manabu Funayama, Tomohiro Ishimaru, Hirofumi Teranishi, Taku Hatano, Kei-Ichi Ishikawa, Yutaka Oji, Taiji Tsunemi, Yuta Ishiguro, Kensuke Daida, Yoko Imamichi, Noriko Nishikawa, Takashi Ueno, Yoshiki Miura, Shogo Ohuchi, Tetsushi Kataura, Nobutaka Hattori, Shinji Saiki   +24 more
doaj   +1 more source

Effects of levodopa on gut bacterial antibiotic resistance in Parkinson’s disease rat

Frontiers in Aging Neuroscience, 2023
The second most prevalent neurodegenerative ailment, Parkinson’s disease (PD), is characterized by both motor and non-motor symptoms. Levodopa is the backbone of treatment for PD at the moment.
Shuo Sheng, Xianwei Li, Shuo Zhao, Changqing Zheng, Feng Zhang, Feng Zhang, Feng Zhang   +6 more
doaj   +1 more source

Catecholamine-Based Treatment in AD Patients: Expectations and Delusions. [PDF]

, 2015
In Alzheimer disease, the gap between excellence of diagnostics and efficacy of therapy is wide. Despite sophisticated imaging and biochemical markers, the efficacy of available therapeutic options is limited.
Alessandro eStefani, Alessandro eStefani, Atticus H Hainsworth, Claudio eLiguori, Enrica eOlivola, Giacoma eAngileri, Mariangela ePierantozzi, Salvatore eGalati, Valentina eSaviozzi, Vincenza eD’Angelo   +9 more
core   +3 more sources

Pharmacokinetics and tolerability of inhaled levodopa from a new dry-powder inhaler in patients with Parkinson’s disease

Therapeutic Advances in Chronic Disease, 2019
Background: Inhaled levodopa may quickly resolve off periods in Parkinson’s disease. Our aim was to determine the pharmacokinetics and tolerability of a new levodopa dry-powder inhaler.
Marianne Luinstra, Wijnand Rutgers, Teus van Laar, Floris Grasmeijer, Anja Begeman, Valmira Isufi, Luc Steenhuis, Paul Hagedoorn, Anne de Boer, Henderik W. Frijlink   +9 more
doaj   +1 more source

Impact of initial treatment on future symptoms and quality of life in Parkinson's disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
Objective To explore the effects of different initial drug treatment on motor symptoms, cognitive function and quality of life in patients with Parkinson's disease (PD).
LI Yu⁃wang, DONG Meng, CHEN Xue⁃jiao, WANG Min, LI Xin, CHEN Lei   +5 more
doaj   +1 more source

Incidence of mild cognitive impairment and dementia in Parkinson's disease: The Parkinson's disease cognitive impairment study [PDF]

, 2019
Background: Cognitive impairment in Parkinson's disease (PD) includes a spectrum varying from Mild Cognitive Impairment (PD-MCI) to PD Dementia (PDD). The main aim of the present study is to evaluate the incidence of PD-MCI, its rate of progression to ...
Baschi R., Cicero C. E., Davi M., Luca A., Monastero R., Mostile G., Nicoletti A., Pilati L., Restivo V., Zappia M.   +9 more
core   +1 more source

Genetic deletion of Rhes or pharmacological blockade of mTORC1 prevent striato-nigral neurons activation in levodopa-induced dyskinesia

Neurobiology of Disease, 2016
Ras homolog enriched in striatum (Rhes) is a small GTP-binding protein that modulates signal transduction at dopamine receptors, and also activates mammalian target of rapamycin complex 1 (mTORC1). Rhes binding to mTORC1 is hypothesized to play a role in
Alberto Brugnoli, Francesco Napolitano, Alessandro Usiello, Michele Morari   +3 more
doaj   +1 more source

Expanding the spectrum of impulse control disorders in Parkinson's disease: the phenomenology of sweet craving [PDF]

, 2013
Thesis (M.A.)--Boston UniversityBackground: The recognized spectrum of impulse control disorders in Parkinson’s disease (PD) includes pathologic gambling, hypersexuality, compulsive buying, and binge eating, and is commonly related to exposure to ...
Brown, Caitlin Harrington
core   +1 more source

Acoustic Measures Capture Speech Dysfunction in Spinocerebellar Ataxia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxias (SCA) are hereditary cerebellar degenerative disorders with a common feature of dysarthria, involving impaired phonatory and articulatory control of speech, thereby affecting social communication. In this study, we investigated whether acoustic measures could objectively measure speech dysfunction and identify
Zena Fadel, Charlotte Hennessey, Hannah Lee, Pia Parekh, Sheng‐Han Kuo, Ami Kumar   +5 more
wiley   +1 more source

Prescribing patterns and determinants for elderly patients with Parkinson's disease in Japan: a retrospective observational study using insurance claims databases

Frontiers in Neurology, 2023
BackgroundThis study aimed to determine real-world prescribing patterns and determinants for Japanese patients with Parkinson's disease (PD), with a focus on patients ≥75 years.MethodsThis was a retrospective, observational, longitudinal study of ...
Morinobu Seki, Yayoi Kawata, Ayako Hayashi, Masaki Arai, Shinji Fujimoto   +4 more
doaj   +1 more source