Results 1 to 10 of about 6,081 (225)

Levosimendan for sepsis-induced myocardial dysfunction: friend or foe? [PDF]

Frontiers in Cardiovascular Medicine
Sepsis-induced myocardial dysfunction (SIMD) involves reversible myocardial dysfunction. The use of inotropes can restore adequate cardiac output and tissue perfusion, but conventional inotropes, such as dobutamine and adrenaline, have limited efficacy ...
Xinxin Du, Xinxin Du, Fang Xiong, Yafei Hou, Xiangyou Yu, Pengfei Pan   +5 more
doaj   +2 more sources

Does Levosimendan hasten veno-arterial ECMO weaning? A propensity score matching analysis [PDF]

Annals of Intensive Care
Background Preliminary evidence from small, single-center studies suggests levosimendan may improve the likelihood of successful venoarterial extracorporeal membrane oxygenation (VA-ECMO) weaning in patients with cardiogenic shock.
Nicolas Paulo, Antoine Kimmoun, David Hajage, Pierre Hubert, David Levy, Marc Pineton de Chambrun, Juliette Chommeloux, Ouriel Saura, Grégoire Del Marmol, Quentin Moyon, Guillaume Hékimian, Melchior Gautier, Charles Edouard Luyt, Guillaume Lebreton, Bruno Levy, Alain Combes, Matthieu Schmidt   +16 more
doaj   +2 more sources

Levosimendan, a Promising Pharmacotherapy in Cardiogenic Shock: A Comprehensive Review [PDF]

European Cardiology Review
Cardiogenic shock (CS) is a critical condition with high mortality rate, as the current management of CS presents significant challenges. Exploration of more effective therapies is necessitated.
Hendri Susilo, Fan Maitri Aldian, Citrawati Dyah Kencono Wungu, Mochamad Yusuf Alsagaff, Henry Sutanto, Chaq El Chaq Zamzam Multazam   +5 more
doaj   +2 more sources

Renal Response to Levosimendan in Advanced Chronic Heart Failure Patients Listed for Heart Transplantation Predicts Early Postoperative Renal Function Course [PDF]

Journal of Cardiovascular Development and Disease
Background: Beyond its established inotropic effects, levosimendan has been reported to enhance renal function in patients with chronic heart failure. In this study, we investigated whether changes in renal function following levosimendan administration ...
Gregor Zemljic, Gregor Poglajen, Sabina Frljak, Andraz Cerar, Renata Okrajsek, Miran Sebestjen, Ivan Knezevic, Bojan Vrtovec   +7 more
doaj   +2 more sources

The Effects of Levosimendan on Microcirculation and Peripheral Perfusion in Septic Shock: A Pilot Study [PDF]

Life
Septic patients can show multiorgan failure even after an apparent recovery of hemodynamic stability. The underlying mechanism is unclear, but the main pathological element is microcirculation impairment, leading to insufficient oxygen delivery.
Veronica Gagliardi, Francesco Ceccherelli, Antonello Lovato, Giuseppe Gagliardi   +3 more
doaj   +2 more sources

Levosimendan vs. dobutamine: outcomes for acute heart failure patients on β‐blockers in SURVIVE† [PDF]

European Journal of Heart Failure, 2009
Alexandre Mebazaa, John G Cleland
exaly   +2 more sources

The Coadministration of Levosimendan and Exenatide Offers a Significant Cardioprotective Effect to Isolated Rat Hearts against Ischemia/Reperfusion Injury

Journal of Cardiovascular Development and Disease, 2022
(1) Background: The present study aims to investigate the effect of administration of Levosimendan and Exenatide in various concentrations, as well as of the coadministration of those agents in an ischemia–reperfusion injury isolated heart model.
Vasileios Leivaditis, Efstratios Koletsis, Nikolaos Tsopanoglou, Nikolaos Charokopos, Cristian D’Alessandro, Konstantinos Grapatsas, Efstratios Apostolakis, Effrosyni Choleva, Maria Plota, Andreas Emmanuil, Manfred Dahm, Dimitrios Dougenis   +11 more
doaj   +1 more source

Clinical outcomes of levosimendan versus dobutamine in patients with acute decompensated heart failure with reduced ejection fraction and impaired renal function

Indian Heart Journal, 2021
To assess the clinical outcomes of levosimendan and dobutamine in patients with acute decompensated heart failure with reduced ejection fraction and impaired renal function in Indian scenario.
Basil John, Pharm D, Mariya Babu, Pharm D, Sandramol shaji, Pharm D, Suja Abraham, Jabir Abdullakutty   +4 more
doaj   +1 more source

Use of levosimendan combined with Shenfu injection to treat acute heart failure patients with hypotension: a prospective randomized controlled single-blind study

BMC Cardiovascular Disorders, 2022
Background Levosimendan can improve clinical symptoms and the cardiorenal rescue success rate, and stabilize hemodynamic parameters in individuals suffering from acute decompensated heart failure.
Miaomiao Li, Yue Zhang, Qianli Wan, Yiou Li, Tianzhen Qu, Fang Yuan   +5 more
doaj   +1 more source

Does the cardiovascular drug levosimendan prevent iodinated contrast medium nephrotoxicity with glycerol aggravation in rats?

European Radiology Experimental, 2021
Background We investigated whether levosimendan prevents contrast medium nephrotoxicity with glycerol aggravation in rats. Methods Forty-eight Wistar albino rats were assigned to eight groups (n = 6 × 8).
Irmak Durur-Subasi, Duygu Kose, Muhammed Yayla, Busra Sirin, Adem Karaman, Ilknur Calik, Fatih Alper   +6 more
doaj   +1 more source