Results 31 to 40 of about 3,869 (167)

Levosimendan: The current situation and new prospects

Revista Portuguesa de Cardiologia, 2014
Levosimendan is a pyridazinone-dinitrile derivative with positive inotropic and vasodilatory effects that has beneficial effects on myocardial performance.In previous randomized studies levosimendan improved hemodynamics and clinical course, but its ...
Nuno Moreno, Marta Tavares-Silva, André P. Lourenço, José Oliveira-Pinto, Tiago Henriques-Coelho, Adelino F. Leite-Moreira   +5 more
doaj   +1 more source

Heart–Lung Interactions in Pulmonary Hypertension due to Heart Failure With Preserved Ejection Fraction

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review considers heart–lung interactions in pulmonary hypertension due to heart failure with preserved ejection fraction across scales, including organ, tissue, and cell scales. Key knowledge gaps in preclinical disease models, tools for clinical phenotyping, and underlying biological mechanisms are identified for future studies.
Pratima Prabala, Farhan Raza, Naomi C. Chesler   +2 more
wiley   +1 more source

Levosimendán preoperatorio en cirugía coronaria con disfunción ventricular severa: ¿tiene sentido?

Cirugía Cardiovascular, 2021
Resumen: Introducción y objetivos: Numerosos estudios han demostrado los beneficios del levosimendán en pacientes con insuficiencia cardiaca crónica y aguda; sin embargo, los resultados son contradictorios cuando se analiza el uso de levosimendán previo
Elena Roselló-Díez, Eduardo Astrosa, Sandra Casellas, Manel Tauron, Josefina Galán, Antonino Ginel, José Montiel   +6 more
doaj   +1 more source

Mitral Transcatheter Edge‐to‐Edge Repair in Patients With Advanced Heart Failure: A Single‐Center Experience and Insights Into Anatomical and Clinical Determinants of Procedural Complexity

Catheterization and Cardiovascular Interventions, Volume 107, Issue 6, Page 2013-2021, May 1, 2026.
ABSTRACT Background Advanced heart failure (HF) remains a clinical challenge, and mitral transcatheter edge‐to‐edge repair (M‐TEER) has emerged as a potential bridging strategy. Aims To describe the clinical outcomes of M‐TEER in a single‐center cohort of patients with advanced HF and to identify anatomical and clinical features potentially associated ...
Pedro Castilhos de Freitas Crivelaro, Laura Hastenteufel, Guilherme Pinheiro Machado, Felipe Fuchs, Antonio Pinotti, Marco Vugman Wainstein, Nadine Clausell, Lívia Adams Goldraich, Felipe Homem Valle   +8 more
wiley   +1 more source

Levosimendan Increases Survival in a D-Galactosamine and Lipopolysaccharide Rat Model

Biomedicines, 2022
Levosimendan, a calcium sensitizer, has an organ protective profile through the inhibition of inflammatory mediators and cytokines in critical conditions, such as heart failure, ischemia-reperfusion injury, and sepsis. The survival effect of levosimendan
Tatsuma Sakaguchi, Fusao Sumiyama, Masaya Kotsuka, Masahiko Hatta, Terufumi Yoshida, Mikio Hayashi, Masaki Kaibori, Mitsugu Sekimoto   +7 more
doaj   +1 more source

Drainage of Pleural Effusion in the Intensive Care Unit (DOPE‐ICU) Feasibility Trial—Protocol and Statistical Analysis Plan

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 5, May 2026.
ABSTRACT Pleural effusions are common in adult intensive care unit (ICU) patients with respiratory failure. Ultrasonography‐guided therapeutic pleural drainage is widely used and associated with improved oxygenation and ventilatory parameters, but no randomised clinical trial data exist.
Marie Schjødt Worm, Morten Hylander Møller, Niels Henrik Bruun, Anne Craveiro Brøchner, Morten Heiberg Bestle, Bodil Steen Rasmussen, Olav Lilleholt Schjørring   +6 more
wiley   +1 more source

Use of Levosimendan in Cardiac Anesthesiology

Общая реаниматология, 2011
The authors consider the main aspects of the rational use of the novel inotropic drug levosimendan in cardiosurgical patients on the basis of the results of the trials described in the literature and on their own findings in this review.
L. A. Krichevsky, V. Yu. Rybakov, O. G. Guseva, I. E. Kharlamova, A. Yu. Lyamin   +4 more
doaj   +1 more source

Lifesaving Compassionate‐Use of Sotatercept in a 12‐Year‐old With Idiopathic Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT Pediatric idiopathic pulmonary arterial hypertension (IPAH) refractory to maximal medical therapy is associated with high morbidity and mortality, and therapeutic options remain limited. We describe a 12‐year‐old girl with end‐stage IPAH who developed acute decompensated right heart failure despite triple combination therapy, including high ...
Weronika Pelczar‐Płachta, Rafał Surmacz, Waldemar Bobkowski   +2 more
wiley   +1 more source

Mortality Predictions Including Pre‐Admission Functional Status in ICU Patients With Delirium—A Substudy of the AID‐ICU Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 4, April 2026.
ABSTRACT Purpose Pre‐admission functional status affects patients' ability to overcome the deteriorating effects of acute critical illness. We aimed to develop a clinical prediction model for 90‐day and 1‐year mortality based on pre‐admission data, including functional status, in adult delirious ICU patients. Methods We included participants randomized
Lone M. Poulsen, Andreas W. Rosen, Nina C. Andersen‐Ranberg, Camilla B. Mortensen, Anders Perner, Stine Estrup, Bodil S. Rasmussen, Ole Mathiesen   +7 more
wiley   +1 more source

From Thrombolysis to Transplant: Navigating the Storm of Delayed STEMI and Cardiogenic Shock

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Delayed STEMI presentation can cause extensive myocardial necrosis, left ventricular thrombus, cardiogenic shock, and progression to end‐stage heart failure despite reperfusion. Early recognition and timely transfer to specialized shock centers are critical.
Syed Rafay Hussain Zaidi, Muhammad Sheraz Hameed, Muhammad Ahsan, Hamza Ishfaq, Ali Iqbal, Azka Mirza, Sadia Rekhum, Muhammad Sohaib Alvi, Muhammad Usama Naveed   +8 more
wiley   +1 more source