Results 51 to 60 of about 9,011 (201)

Drainage of Pleural Effusion in the Intensive Care Unit (DOPE‐ICU) Feasibility Trial—Protocol and Statistical Analysis Plan

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 5, May 2026.
ABSTRACT Pleural effusions are common in adult intensive care unit (ICU) patients with respiratory failure. Ultrasonography‐guided therapeutic pleural drainage is widely used and associated with improved oxygenation and ventilatory parameters, but no randomised clinical trial data exist.
Marie Schjødt Worm, Morten Hylander Møller, Niels Henrik Bruun, Anne Craveiro Brøchner, Morten Heiberg Bestle, Bodil Steen Rasmussen, Olav Lilleholt Schjørring   +6 more
wiley   +1 more source

Levosimendan: Perpetuum mobile? [PDF]

European Heart Journal, 2007
We read with great interest the well-written review about levosimendan by De Luca et al. 1 Levosimendan is certainly an interesting drug that appears to deliver favourable effects in patients with acute heart failure. Numerous studies have demonstrated the positive inotropic …
Stefan, Agewall, Dan, Atar
openaire   +2 more sources

Levosimendan exerts anticonvulsant properties against PTZ-induced seizures in mice through activation of nNOS/NO pathway: Role for KATP channel [PDF]

, 2017
Aims Although approving new anticonvulsants was a major breakthrough in the field of epilepsy control, so far we have met limited success in almost one third of patients suffering from epilepsy and a definite and reliable method is yet to be found ...
Aleyasin, Ali Reza., Amini-Khoei, Hossein., Amiri, Shayan., Dehpour, Ahmad Reza., Ghasemi, Keyvan., Gooshe, Maziar., Mojahedi, Payam., Tabaeizadeh, Mohammad., Vafaei, Ali., Yousefi, Farbod.   +9 more
core  

Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti‐inflammation, anti‐apoptosis, and ERK activation

FEBS Open Bio, 2021
ATP‐sensitive potassium channels (KATPs) have protective effects in ischemia–reperfusion‐induced injuries and can be activated by levosimendan. This study investigated the effects of levosimendan on renal injury, inflammation, apoptosis, and survival in ...
Lei Tian, Shiwei Wang, Li Zhao, Xiaoye Lu, Changqing Zhu, Hao Gong, Weiqiang Yang   +6 more
doaj   +1 more source

Mortality Predictions Including Pre‐Admission Functional Status in ICU Patients With Delirium—A Substudy of the AID‐ICU Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 4, April 2026.
ABSTRACT Purpose Pre‐admission functional status affects patients' ability to overcome the deteriorating effects of acute critical illness. We aimed to develop a clinical prediction model for 90‐day and 1‐year mortality based on pre‐admission data, including functional status, in adult delirious ICU patients. Methods We included participants randomized
Lone M. Poulsen, Andreas W. Rosen, Nina C. Andersen‐Ranberg, Camilla B. Mortensen, Anders Perner, Stine Estrup, Bodil S. Rasmussen, Ole Mathiesen   +7 more
wiley   +1 more source

Effect of levosimendan on prognosis in adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials

Critical Care, 2017
Background Small trials suggest that levosimendan is associated with a favorable outcome in patients undergoing cardiac surgery. However, recently published larger-scale trials did not provide evidence for a similar benefit from levosimendan.
Qi-Hong Chen, Rui-Qiang Zheng, Hua Lin, Jun Shao, Jiang-quan Yu, Hua-Ling Wang   +5 more
doaj   +1 more source

Predictivity of in vitro non-clinical cardiac contractility assays for inotropic effects in humans – A Literature Search [PDF]

, 2015
Adverse drug effects on the cardiovascular system is a major cause of compound attrition throughout compound discovery and development. There are many ways by which drugs can affect the cardiovascular system, including effects on the electrocardiogram ...
Gharanei, Mayel, Maddock, Helen L., Wallis, R.   +2 more
core   +1 more source

From Thrombolysis to Transplant: Navigating the Storm of Delayed STEMI and Cardiogenic Shock

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Delayed STEMI presentation can cause extensive myocardial necrosis, left ventricular thrombus, cardiogenic shock, and progression to end‐stage heart failure despite reperfusion. Early recognition and timely transfer to specialized shock centers are critical.
Syed Rafay Hussain Zaidi, Muhammad Sheraz Hameed, Muhammad Ahsan, Hamza Ishfaq, Ali Iqbal, Azka Mirza, Sadia Rekhum, Muhammad Sohaib Alvi, Muhammad Usama Naveed   +8 more
wiley   +1 more source

Dopamine is associated with the worst outcome among inotropes used in acute heart failure: observations from the ESC-HF-LT registry [PDF]

, 2017
Abstrac
Akiyama, Eiichi, Chioncel, Ovidiu, Crespo-Leiro, María Generosa, Filippatos, Gerasimos, Gayat, Etienne, Lund, Lars H., Maggioni, Aldo P., Mebazaa, Alexandre, Motiejunaite, J., Ruschitzka, Frank   +9 more
core   +2 more sources

Biventricular Impella Support for Ventricular Tachycardia Ablation in a Patient With Severe Dilated Cardiomyopathy

Clinical Case Reports, Volume 14, Issue 3, March 2026.
VT ablation with percutaneous biventricular Impella support in a patients with non‐ischemic dilated cardiomyopathy and severe biventricular failure. Segmented Inheart CT, angulation a.p. (a) and LAO (c). Segmentation revealed the prior ablation site (blue arrow) and extensive intramural fibrotic tissue (asterisk).
Madeleine Tydecks, Theresa Reiter, Gabriele Hessling, Isabel Deisenhofer, Mohammad Al Fayad   +4 more
wiley   +1 more source