Results 61 to 70 of about 3,869 (167)

Prophylactic use of levosimendan in pediatric patients undergoing cardiac surgery: a prospective randomized controlled trial

Critical Care, 2019
Background The administration of levosimendan prophylactically to patients undergoing cardiac surgery remains a controversial practice, and few studies have specifically assessed the value of this approach in pediatric patients.
Anbiao Wang, Chaomei Cui, Yiou Fan, Jie Zi, Jie Zhang, Guanglai Wang, Fang Wang, Jun Wang, Qi Tan   +8 more
doaj   +1 more source

Effect of levosimendan, a calcium sensitizer, on cisplatin-induced nephrotoxicity in rats

Toxicology Reports, 2019
We investigated the effect of levosimendan on cisplatin (Cis)-induced nephrotoxicity. Rats were divided into four groups (n = 6). The first and second groups received normal saline (control) and intraperitoneal (i.p.) cisplatin (6 mg/kg) on day 7 ...
Aly M. Abdelrahman, Yousuf Al Suleimani, Asem Shalaby, Mohammed Ashique, Priyadarsini Manoj, Hasna Al-Saadi, Badreldin H. Ali   +6 more
doaj   +1 more source

Nurse‐coordinated multidisciplinary comprehensive heart failure management programme: A propensity‐matched trial

ESC Heart Failure, Volume 12, Issue 6, Page 4160-4170, December 2025.
Abstract Aims Despite therapeutic advancements, the prognosis of heart failure (HF) remains poor, with high rates of mortality and readmission, particularly following a HF exacerbation. This study aimed to evaluate the effects of a nurse‐coordinated multidisciplinary comprehensive HF management programme on HF patients.
Cecilia Miu‐Ching Chan, Polly Wai‐Chi Li, Derek Pok‐Him Lee, Esmond Yan‐Hang Fong, Ivy Sin‐Yee Ng, Samantha Ki‐Man Chiu, Clara Woon‐Shan Fok, Frederick Kin‐Wa Li, Shirley Ka‐Wai Lee, Karen K. Y. Ho, Wilson Y. S. Leung, Cathy Cheuk‐Sum Chan, Cindy Yiu‐Ning Tsang, Michael Kang‐Yin Lee   +13 more
wiley   +1 more source

The therapeutic effect of levosimendan in patients with prolonged ventilator weaning and cardiac dysfunction

Journal of International Medical Research
Objective To explore the therapeutic effect of levosimendan in patients with prolonged ventilator weaning and cardiac dysfunction. Method Patients with prolonged ventilator weaning and cardiac dysfunction were randomly allocated to receive conventional ...
Fang Xiong, Zongjun Hu, Chao Liu, Kexiang Zhang, Qilong Zhou, Jianguo Chen, Hua Lu, Xi Yue, Jianxin Zhao, Pengfei Pan   +9 more
doaj   +1 more source

Impact of levosimendan on weaning from peripheral venoarterial extracorporeal membrane oxygenation in intensive care unit

Annals of Intensive Care, 2019
Background Few data are available on the impact of levosimendan in refractory cardiogenic shock patients undergoing peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO). The aim of this study was to evaluate the impact of levosimendan on
Shamir Vally, Cyril Ferdynus, Romain Persichini, Bruno Bouchet, Eric Braunberger, Hugo Lo Pinto, Olivier Martinet, David Vandroux, Thomas Aujoulat, Jérôme Allyn, Nicolas Allou   +10 more
doaj   +1 more source

Synergistic Effects of Moderate Therapeutic Hypothermia and Levosimendan on Cardiac Function and Survival After Asphyxia‐Induced Cardiac Arrest in Rats

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background This study investigated whether levosimendan, an inotropic calcium sensitizer, when combined with moderate therapeutic hypothermia, may exert synergistic benefits on post–cardiac arrest myocardial dysfunction and improve outcomes.
Chih‐Hung Wang, Wei‐Tien Chang, Min‐Shan Tsai, Chien‐Hua Huang, Wen‐Jone Chen   +4 more
doaj   +1 more source

Worsening versus advanced heart failure: Management and challenges

ESC Heart Failure, Volume 12, Issue 6, Page 3856-3868, December 2025.
Clinical feature, circulating biomarkers and therapeutic management of patients with WHF versus AdvHF. Abbreviations: AdvHF, advanced heart failure; HF, heart failure; HTx, heart transplant; GDMT, guideline‐directed medical therapy; MCS, mechanical circulatory support; NYHA, New York Heart Association; WHF, worsening heart failure.
Alberto Palazzuoli, Marco Giuseppe Del Buono, Giulia La Vecchia, Stephen J. Greene, Andrew P. Ambrosy, Ovidiu Chioncel, Finn Gustafsson, Selim R. Krim, Carl J. Lavie, Marianna Adamo, Tuvia Ben Gal, Oliviana Geavlete, Laura Antohi, Giuseppe Rosano, Sean Collins, Filippo Crea   +15 more
wiley   +1 more source

Levosimendan is superior to epinephrine on coronary flow for lipid-base resuscitation of bupivacaine-induced asystole in the isolated rat heart

BMC Anesthesiology, 2018
Background Successful resuscitation from asystole induced by bupivacaine requires the reestablishment of a sufficient coronary flow (CF) quickly. This study was designed to test whether levosimendan was superior to epinephrine in the reestablishment of ...
Hongfei Chen, Fangfang Xia, Zhousheng Jin, Kejian Shi, Yun Xia, Le Liu, Thomas J. Papadimos, Xuzhong Xu, Limei Chen   +8 more
doaj   +1 more source

Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT

Efficacy and Mechanism Evaluation, 2018
Background: In septic shock, cardiovascular resuscitation using catecholamine vasopressors and inotropes is standard therapy, but catecholamines have important side effects.
Anthony C Gordon, Shalini Santhakumaran, Farah Al-Beidh, Robert ML Orme, Gavin D Perkins, Mervyn Singer, Daniel F McAuley, Alexina J Mason, Josie K Ward, Kieran P O’Dea, Timothy Felton, Mary Cross, Janis Best-Lane, Jonas Lexow, Ashley Campbell, Deborah Ashby   +15 more
doaj   +1 more source

Perioperative Use of Levosimendan in Patients with Severe Left Ventricular Dysfunction Undergoing Cardiac Surgery A Systematic Review and Meta-analysis

Ain Shams Medical Journal
Background: Levosimendan is a calcium-sensitizing ionodilator. However, the current level of clinical evidence is insufficient to determine the clinical value of levosimendan in patients with severe left ventricular dysfunction subjected to cardiac ...
Ramy Reda, Ahmed Fouad, Osama Abd Elhamed, Ahmed Mansour   +3 more
doaj   +1 more source