Results 31 to 40 of about 6,081 (225)

Levosimendan in Cardiac Surgery

Journal of Cardiothoracic and Vascular Anesthesia, 2005
Levosimendan is a new calcium sensitizer with inodilatory properties. There is growing clinical experience with levosimendan given to cardiac surgical patients. The aim of this report was to evaluate the effects of perioperative use of levosimendan in surgical patients with high perioperative risk, compromised left ventricular (LV) function, or ...
K Siirilä, Raili Suojaranta-Ylinen, Veli-Pekka Harjola   +2 more
openaire   +4 more sources

Inhaled levosimendan versus intravenous levosimendan in patients with pulmonary hypertension undergoing mitral valve replacement

Annals of Cardiac Anaesthesia, 2018
Context: Inhaled levosimendan may act as selective pulmonary vasodilator and avoid systemic side effects of intravenous levosimendan, which include decrease in systemic vascular resistance (SVR) and systemic hypotension, but with same beneficial effect ...
Tanveer Singh Kundra, P S Nagaraja, K S Bharathi, Parminder Kaur, N Manjunatha   +4 more
doaj   +1 more source

Inoprotection: The Perioperative Role of Levosimendan [PDF]

Anaesthesia and Intensive Care, 2007
Levosimendan is emerging as a novel cardioprotective inotrope. Levosimendan augments myocardial contractility by sensitising contractile myofilaments to calcium without increasing myosin adenosine triphosphatase activity or oxygen consumption. Levosimendan activates cellular adenosine triphosphate-dependent potassium channels, a mechanism which is ...
Christine E. Wright, Colin Royse, Colin Royse, Alistair Royse, Alistair Royse, Soeding Pe, James A. Angus   +6 more
openaire   +3 more sources

Levosimendán preoperatorio en cirugía coronaria con disfunción ventricular severa: ¿tiene sentido?

Cirugía Cardiovascular, 2021
Resumen: Introducción y objetivos: Numerosos estudios han demostrado los beneficios del levosimendán en pacientes con insuficiencia cardiaca crónica y aguda; sin embargo, los resultados son contradictorios cuando se analiza el uso de levosimendán previo
Elena Roselló-Díez, Eduardo Astrosa, Sandra Casellas, Manel Tauron, Josefina Galán, Antonino Ginel, José Montiel   +6 more
doaj   +1 more source

Transdermal delivery of levosimendan

European Journal of Pharmaceutical Sciences, 2000
The aim of this study was to determine if transdermal penetration of levosimendan, a novel positive inotropic drug, could be enhanced and controlled by formulation modifications. Penetration of levosimendan across human epidermis in vitro was determined using abdominal excised skin and diffusion cells.
Jukka Mönkkönen, Jouni Hirvonen, Arto Urtti, Juha Kiesvaara, Lasse Lehtonen, Saila Antila, Riitta Valjakka-Koskela   +6 more
openaire   +3 more sources

Levosimendan Increases Survival in a D-Galactosamine and Lipopolysaccharide Rat Model

Biomedicines, 2022
Levosimendan, a calcium sensitizer, has an organ protective profile through the inhibition of inflammatory mediators and cytokines in critical conditions, such as heart failure, ischemia-reperfusion injury, and sepsis. The survival effect of levosimendan
Tatsuma Sakaguchi, Fusao Sumiyama, Masaya Kotsuka, Masahiko Hatta, Terufumi Yoshida, Mikio Hayashi, Masaki Kaibori, Mitsugu Sekimoto   +7 more
doaj   +1 more source

Levosimendan: The current situation and new prospects

Revista Portuguesa de Cardiologia, 2014
Levosimendan is a pyridazinone-dinitrile derivative with positive inotropic and vasodilatory effects that has beneficial effects on myocardial performance.In previous randomized studies levosimendan improved hemodynamics and clinical course, but its ...
Nuno Moreno, Marta Tavares-Silva, André P. Lourenço, José Oliveira-Pinto, Tiago Henriques-Coelho, Adelino F. Leite-Moreira   +5 more
doaj   +1 more source

Renal Effects of Levosimendan: A Consensus Report [PDF]

Cardiovascular Drugs and Therapy, 2013
Renal dysfunction is common in clinical settings in which cardiac function is compromised such as heart failure, cardiac surgery or sepsis, and is associated with high morbidity and mortality. Levosimendan is a calcium sensitizer and potassium channel opener used in the treatment of acute heart failure.
Yilmaz MB, Grossini E, Silva Cardoso JC, Édes I, FEDELE, Francesco, Pollesello P, Kivikko M, Harjola VP, Hasslacher J, Mebazaa A, MORELLI, Andrea, le Noble J, Oldner A, Oulego Erroz I, Parissis JT, Parkhomenko A, Poelzl G, Rehberg S, Ricksten SE, Rodríguez Fernández LM, Salmenperä M, Singer M, Treskatsch S, Vrtovec B, Wikström G.   +24 more
openaire   +7 more sources

Levosimendan improves cardiac function and myocardial efficiency in rats with right ventricular failure

Pulmonary Circulation, 2017
Levosimendan is an inotropic and vasodilator drug, which is known to improve cardiac function in animal models of right ventricular (RV) failure. The effects of levosimendan on oxygen consumption and myocardial efficiency in the failing RV is unknown. We
Mona S. Hansen, Asger Andersen, Lars P. Tolbod, Nils H. Hansson, Roni Nielsen, Anton Vonk-Noordegraaf, Jens Erik Nielsen-Kudsk   +6 more
doaj   +1 more source

Levosimendan in Acute Pulmonary Embolism [PDF]

Anaesthesia and Intensive Care, 2007
Levosimendan has been used successfully in the treatment of ischaemic cardiac failure and myocardial stunning. There is growing evidence from both human and animal experiments that levosimendan has particularly favourable effects on the right ventricle. We describe a case of life-threatening pulmonary embolus supported by the use of levosimendan.
Bruce Powell, Bruce Powell, D. Simes
openaire   +3 more sources