Results 31 to 40 of about 12,531 (249)

Treatment with levosimendan in an experimental model of early ventilator-induced diaphragmatic dysfunction

Drug Target Insights, 2023
Introduction: Mechanical ventilation (MV) is a life-saving approach in critically ill patients. However, it may affect the diaphragmatic structure and function, beyond the lungs.
Vanessa Zambelli, Emma J. Murphy, Paolo Del Vecchio, Laura Rizzi, Roberto Fumagalli, Emanuele Rezoagli, Giacomo Bellani   +6 more
doaj   +1 more source

Levosimendan in critical illness: A literature review [PDF]

, 2014
Levosimendan, the active enantiomer of simendan, is a calcium sensitizer developed for treatment of decompensated heart failure, exerts its effects independently of the beta adrenergic receptor and seems beneficial in cases of severe, intractable heart ...
Franchi, Federico, Karanikolas, Menelaos, Muzzi, Luigi, Pierrakos, Charalampos, Scolletta, Sabino, Velissaris, Dimitrios   +5 more
core   +2 more sources

The Perioperative Use of Levosimendan as a Means of Optimizing the Surgical Outcome in Patients with Severe Heart Insufficiency Undergoing Cardiac Surgery

Journal of Cardiovascular Development and Disease, 2023
Background: Postoperative myocardial dysfunction following cardiac surgery is a relatively common occurrence. Levosimendan, a calcium sensitizer and inotropic drug, has shown potential in improving outcomes for patients with low preoperative ejection ...
Vasileios Leivaditis, Konstantinos Grapatsas, Anastasia Papaporfyriou, Michail Galanis, Efstratios Koletsis, Nikolaos Charokopos, Erich Haussmann, Vladislav Kaplunov, Athanasios Papatriantafyllou, Manfred Dahm   +9 more
doaj   +1 more source

Role of calcium desensitization in the treatment of myocardial dysfunction after deep hypothermic circulatory arrest [PDF]

, 2013
Introduction Rewarming from deep hypothermic circulatory arrest (DHCA) produces calcium desensitization by troponin I (cTnI) phosphorylation which results in myocardial dysfunction.
Faggian, Giuseppe, Giacomazzi, Alice, Hallström, Seth, Linardi, Daniele, Luciani, Giovanni, Mazzucco, Alessandro, Milani, Elisabetta, Rungatscher, Alessio, Scarabelli, Tiziano M, Tessari, Maddalena   +9 more
core   +3 more sources

Use of levosimendan in hemodynamic management of heart failure in two neonates with intracranial arteriovenous shunts: a case series

Italian Journal of Pediatrics, 2023
Background The hemodynamic status of newborns with intracranial arteriovenous shunts (AVSs) may be extremely complex. Mini-invasive hemodynamic monitoring through innovative techniques such as Near-Infrared Spectroscopy (NIRS) and Pressure Recording ...
Francesca Landolfo, Paola Giliberti, Domenico Umberto De Rose, Flaminia Pugnaloni, Alessandra Santisi, Claudia Columbo, Ludovica Martini, Maria Paola Ronchetti, Luca Di Chiara, Alessandra Toscano, Carlo Gandolfo, Andrea Dotta, Irma Capolupo   +12 more
doaj   +1 more source

European experience on the practical use of levosimendan in patients with acute heart failure syndromes [PDF]

, 2005
The novel calcium sensitizer and ATP-dependent potassium channel opener levosimendan has been introduced for routine use in several European countries. Recent reports on clinical experience confirm the positive hemodynamic results and beneficial clinical
Cardoso, JS, Follath, F, Franco, F
core   +1 more source

Inhaled levosimendan versus intravenous levosimendan in patients with pulmonary hypertension undergoing mitral valve replacement

Annals of Cardiac Anaesthesia, 2018
Context: Inhaled levosimendan may act as selective pulmonary vasodilator and avoid systemic side effects of intravenous levosimendan, which include decrease in systemic vascular resistance (SVR) and systemic hypotension, but with same beneficial effect ...
Tanveer Singh Kundra, P S Nagaraja, K S Bharathi, Parminder Kaur, N Manjunatha   +4 more
doaj   +1 more source

Levosimendán preoperatorio en cirugía coronaria con disfunción ventricular severa: ¿tiene sentido?

Cirugía Cardiovascular, 2021
Resumen: Introducción y objetivos: Numerosos estudios han demostrado los beneficios del levosimendán en pacientes con insuficiencia cardiaca crónica y aguda; sin embargo, los resultados son contradictorios cuando se analiza el uso de levosimendán previo
Elena Roselló-Díez, Eduardo Astrosa, Sandra Casellas, Manel Tauron, Josefina Galán, Antonino Ginel, José Montiel   +6 more
doaj   +1 more source

Le lévosimendan en cardiologie et chirurgie cardiaque sous circulation extracorporelle

Avicenna Medical Research, 2023
Introduction : le lévosimendan est un agent inodilatateur utilisé avec succès dans le traitement de l’insuffisance cardiaque aigue et chronique.
Sayad, M Abdelbaki, Mehyaoui
doaj   +1 more source

Calcium sensitizers: What have we learned over the last 25years? [PDF]

, 2018
K
Papp, Gy. Julius, Papp, Zoltán, Pollesello, Piero   +2 more
core   +1 more source