Results 121 to 130 of about 27,301 (241)

The effect of low- and high-dose levothyroxine on the expression, protein level, and function of P-glycoprotein in mice: The effect of levothyroxine on P-gp is variable

, 2023
The study was investigated the effect of different doses of levothyroxine on the mRNA expression, protein level and function of Pgp. Mice were divided into 6 groups as control, low dose levothyroxine, high dose levothyroxine, fexofenadine, low dose ...
Tras, B, Eser Faki, H, Ozdemir Kutahya, Z, Uney, K, Melik Parlak, T   +4 more
core  

Protective effect of levothyroxine with oxidative stress reduction mechanism in ischemic preconditioning model in rat heart

مجله دانشگاه علوم پزشکی گرگان, 2017
Background and Objective: A brief and short duration episode of ischemia is recorded in ischemic preconditioning (IPC). This latter condition provides a status in which large region of heart is protected when prolonged ischemia occurred.
Masoumeh Tajik, Vahid Khori, Abdoljalal Marjani, Shohreh Taziki, Mohammad Ali Zeyghami, Azad Reza Mansourian   +5 more
doaj  

Comparing Blood Pressure in Pregnant Women with Subclinical Hypothyroidism Using Levothyroxine to those with Euthyroid Status

Advanced Biomedical Research
Background: Subclinical hypothyroidism (SCH) is a common condition during pregnancy that can be treated with levothyroxine at a dosage of 0.5–1 mcg/kg/day. If left untreated, the risk of hypertensive disorders of pregnancy increases.
Afsaneh Halili, Mozhgan Kazemzadeh, Alireza Seyfi Ardali, Seyede Shahrbanoo Daniali, Nahid Ardian, Masoomeh Goodarzi-Khoigani   +5 more
doaj   +1 more source

Real‐World Patient Characteristics and Treatment Patterns Among Patients With Interstitial Cystitis (IC)/Bladder Pain Syndrome (BPS)

Reproductive, Female and Child Health, Volume 5, Issue 2, June 2026.
ABSTRACT Objective Interstitial cystitis/bladder pain syndrome (IC/BPS) is linked to bladder and/or pelvic pain, pressure, and discomfort with urinary frequency. Despite guidelines, there is a need for better treatment options. This study analyzed patient demographics, clinical characteristics, and treatment patterns for medications and procedures in ...
Jaromir Mikl, Tiange Yu, Benjamin T. Carter, Andrew Rava, Xin Zhao, Catherine Allende, Amie Devlin, Valentine Pascale, Roger Dmochowski   +8 more
wiley   +1 more source

Liquid and softgel levothyroxine use in clinical practice: state of the art

, 2016
Levothyroxine is recognized as the treatment of choice for hypothyroidism. So far, the tablet levothyroxine has been the formulation almost exclusively used, even though an optimal daily dose of levothyroxine has been unsuccessfully sought and a ...
CENTANNI, Marco, VIRILI, CAMILLA, Trimboli, Pierpaolo, ROMANELLI, Francesco   +3 more
core   +1 more source

Pre‐RAI Monocyte‐to‐Lymphocyte Ratio Predicts Early and Higher Recurrence Risk in Intermediate‐Risk DTC, While PNI and NRI Show No Prognostic Value

Clinical Endocrinology, Volume 104, Issue 6, Page 670-681, June 2026.
ABSTRACT Objective Differentiated thyroid carcinoma (DTC) has an excellent prognosis, but recurrence remains a clinical concern, especially in intermediate‐risk patients. Current stratification systems focus primarily on tumor characteristics, overlooking the host's biological capacity to counteract tumor progression.
Tommaso Piticchio, Francesco Galeano, Salvatore Volpe, Antonio Prinzi, Ignazio Barca, Andrea Scuto, Rosario Le Moli, Giulio Geraci, Andrea Tumminia, Sium Wolde Sellasie, Francesco Pallotti, Francesco Frasca   +11 more
wiley   +1 more source

Phase 1 Study Evaluating the Pharmacokinetics, Dose Proportionality, Bioavailability, and Tolerability of Subcutaneous Levothyroxine Sodium (XP‐8121)

Clinical and Translational Science
Levothyroxine sodium has been the cornerstone of hypothyroidism management worldwide, with daily oral administration (PO) recognized as standard of care.
Richard Fitch, Diane R. Mould, Valentina Conoscenti, Robbie Huang, Dawn Harper   +4 more
doaj   +1 more source

Factors associated with potentially inappropriate medication use, medication underuse and overuse in older adults in the German National Cohort

Journal of Internal Medicine, Volume 299, Issue 6, Page 754-775, June 2026.
Abstract Background Effectively identifying individuals exposed to drug underuse, overuse and potentially inappropriate medication (PIM) in older adults is essential for minimizing preventable drug‐related harms. Methods We analysed data from 54,296 individuals aged 60–74 years from the German National Cohort (NAKO).
Miriam Degen, Ulrike Haug, Oliver H. F. Scholle, Yaw Awuku‐Larbi, Sigrid Carlsson, Nina Ebert, Volker Harth, Anja M. Hauri, Margit Heier, Anne Herrmann, Michael Leitzmann, Jakob Linseisen, Claudia Meinke‐Franze, Nadia Obi, Phil Pendt, Thomas Reinhold, Barbara Thorand, Hermann Brenner, Ben Schöttker   +18 more
wiley   +1 more source

A Bizarre Complication of Levothyroxine Therapy

Indian Journal of Endocrinology and Metabolism, 2021
Aneez Joseph, Kripa Elizabeth Cherian, Nitin Kapoor, Thomas V Paul   +3 more
openaire   +3 more sources

From Resistance to Relief: IV Levothyroxine in Refractory Hypothyroidism Management

Clinical Case Reports
This case report details the clinical scenario of a 27‐year‐old female patient diagnosed with idiopathic refractory hypothyroidism. Despite adherence to prescribed oral levothyroxine therapy, she continued to experience persistent symptoms such as ...
Mohammad Amro, Elias Edward Lahham, Ahmed Jalal Sawafta, Motaz Saifi, Nooreddin Saifi, Fadi Atrash, Salem Billan   +6 more
doaj   +1 more source