Liothyronine for hypothyroidism: a candidate for disinvestment or in need of further research? A value of information analysis [PDF]
BMJ Open, 2021 Objective Medicines with limited evidence of effectiveness are prime candidates for disinvestment. However, investment in further research may be preferable to deimplementation, given that the absence of evidence is not evidence of absence, and research ...
Dyfrig A Hughes +3 more
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Nice guideline on thyroid disease: where does it take us with liothyronine? [PDF]
Thyroid Research, 2020 The new NICE guidelines on thyroid disease and its management do not recommend the routine use of liothyronine, but do not completely rule it out either.
Graham P. Leese
doaj +4 more sources
Case Report: A homozygous selenocysteine insertion sequence-binding protein 2 (SECISBP2) gene mutation in a pediatric patient [PDF]
Frontiers in PediatricsSelenocysteine insertion sequence-binding protein 2 (SECISBP2) is crucial for the biosynthesis of selenoproteins, including iodothyronine deiodinases, which play a vital role in thyroid hormone metabolism.
Lina Almohammadi +5 more
doaj +2 more sources
Role of T3 in Management of Hypothyroidism [PDF]
Indian Journal of Endocrinology and MetabolismThe management of hypothyroidism is based on the assumption that levothyroxine monotherapy normalizes thyroid hormone homeostasis, rendering patients clinically and biochemically euthyroid.
Sanjay Kalra +4 more
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Canadian Endocrinologists' Perspectives on Treatment With Thyroid Hormone Substitutions in Euthyroid and Hypothyroid Patients: A 2023 THESIS Questionnaire Survey. [PDF]
Clin Endocrinol (Oxf)Objective: The practice of treating hypothyroid and euthyroid patients with thyroid hormones varies between countries, as observed in the recent surveys of European thyroid experts, THESIS.
Liu A +11 more
europepmc +3 more sources
Combination therapy of liothyronine and levothyroxine for hypothyroidism-induced dilated cardiomyopathy [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2022 Thyroid hormone plays a vital role in regulating human metabolism. They affect the functions of major organs, such as the brain, liver, skeletal muscle, and heart. Hypothyroidism can lead to dilated cardiomyopathy and decreased heart function.
Youngha Choi +7 more
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Metabolites, 2022 We examined relationships between thyroid hormone (TH) metabolites in humans by measuring 3,5-diiodothyronine (3,5-T2) and 3-iodothyronamine (3-T1AM) levels after liothyronine administration.
Nour Diab +5 more
doaj +1 more source
Frontiers in Endocrinology, 2022 ContextThe pharmacokinetics of liothyronine causes concerns for cardiovascular toxicity. While the effects of sustained increase in serum T3 concentrations are well described, little is known on the effects of acute changes in T3 concentrations due to ...
Shanshan Chen +9 more
doaj +1 more source
A 29-year-old Bodybuilder with Liothyronine-induced Thyrotoxic Hypokalaemic Periodic Paralysis
European Journal of Case Reports in Internal Medicine, 2021 We describe a 29-year-old male bodybuilder with recurrent attacks of myalgia and muscle weakness associated with hypokalaemia and thyrotoxicosis due to abuse of liothyronine.
Querijn van Bokhorst +3 more
doaj +1 more source
Case Reports in Psychiatry, 2022 Background/Objective. Thyrotoxicosis, a condition resulting from excessive peripheral thyroid hormone, is typically accompanied by thyroid function tests demonstrating a high free thyroxine (free T4) with appropriate suppression of thyroid-stimulating ...
Benjamin A. Pallant +2 more
doaj +1 more source