Results 31 to 40 of about 25,504 (178)

Risk of cardiac, neuropsychiatric and musculoskeletal adverse events with levothyroxine: Systematic review

British Journal of Clinical Pharmacology, EarlyView.
Abstract Levothyroxine (LT4) is the standard treatment for hypothyroidism and the most widely prescribed medication worldwide. Although generally safe, regulatory reports list potential cardiac, neuropsychiatric and musculoskeletal adverse events (AEs). Clarifying their clinical relevance is essential.
Bala Swetha Baskaran, Mohammad Ali Omrani, Flory T. Muanda   +2 more
wiley   +1 more source

IKAROS Associated Immunodeficiency and Thrombotic Thrombocytopenic Purpura

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pathogenic variants in IKZF1 (IKAROS) are linked to immunodeficiency, malignancy, and immune dysregulation. We describe a family with a rare IKZF1 variant presenting with humoral immunodeficiency and thrombotic thrombocytopenic purpura (TTP). A non‐consanguineous family was clinically monitored; clinical, immunological, and genetic data (exome
Ilia Spivak, Daniella Magen, Karin Weiss, Tamar Paperna, Suhair Hanna, Amos Etzioni, Adi Miller‐Barmak, Yonatan Butbul Aviel   +7 more
wiley   +1 more source

Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients. [PDF]

PLoS ONE, 2011
CONTEXT: Levothyroxine monotherapy is the treatment of choice for hypothyroid patients because peripheral T4 to T3 conversion is believed to account for the overall tissue requirement for thyroid hormones.
Damiano Gullo, Adele Latina, Francesco Frasca, Rosario Le Moli, Gabriella Pellegriti, Riccardo Vigneri   +5 more
doaj   +1 more source

Qualitative study on occupational anxiety among young thyroid cancer survivors before returning to work

Precision Medical Sciences, EarlyView.
The main aim of this study was to elucidate and clarify the manifestations of occupational anxiety among young postoperative thyroid cancer survivors before returning to work and to explore strategies and support needed to cope upon their return to work. Abstract The purpose of this qualitative study was to understand the manifestations of occupational
Hong Gao, Ping Zhu, Maomao Zhang, Bing Wu, Yun Ning, Xiaoxu Li, Hui Huang, Jinlan Shao, Meiying Zou, Tingting Hu, Liuliu Zhang   +10 more
wiley   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Adhesion molecules in the maternal–fetal interface in healthy pregnancies and preeclampsia

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
This study revealed elevated levels of adhesion molecules in the maternal circulation and reduced levels in the fetal circulation in preeclampsia. The findings suggest systemic maternal endothelial dysfunction in preeclampsia. Lower fetal adhesion molecule levels warrant further study. Abstract Introduction Adhesion molecules are markers of endothelial
Ingrid Kverndalen Frisch, Trond Melbye Michelsen, Tove Lekva, Marie Cecilie Paasche Roland, Ane Cecilie Westerberg   +4 more
wiley   +1 more source

Surgical Outcomes Following Neoadjuvant‐Targeted Therapy for Advanced Differentiated Thyroid Cancer—Real‐World Data

Clinical Endocrinology, EarlyView.
ABSTRACT Background Differentiated thyroid carcinoma (DTC) is typically managed surgically with favourable outcomes. However, surgery may have dire consequences when the tumour invades critical structures. Neoadjuvant therapy with tyrosine kinase inhibitors (TKIs) has emerged as a potential strategy to improve resectability and reduce morbidity in ...
Alexandra Dorman, Genady Shendler, Anton Warshavsky, Nidal Muhanna, Gilad Horowitz, Liyona Kampel Furman, Shahaf Shilo, Ben‐Zion Joshua, Eran Alon, Eric Remer, Galit Avior, Avi Khafif, Orit Gutfeld, Elena Izkhakov, Jobran Mansour, Inbar Finkel   +15 more
wiley   +1 more source

Evaluating the Link Between Thyroid Function Test Results and Levothyroxine Dose in the Management of Hypothyroidism: Can We Improve Dosing Regimes?

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction Over 10 million thyroid function tests (TFTs) are carried out in England each year, most requests coming from primary care. Our previous work showed that only 25% of results for patients being treated with Levothyroxine fell within the TSH/FT4 boundary circumscribing 75% of untreated individuals.
Adrian H. Heald, Lakdasa D. Premawardhana, Peter N. Taylor, Suhani Bahl, Onyebuchi E. Okosieme, Anthony A. Fryer, Antonio Bianco, Colin M. Dayan, Michael P. Stedman   +8 more
wiley   +1 more source

Prevalence of Antenatally Identified Lactation Risk Factors and Risk of Not Fully Breastfeeding at 6 to 8 Weeks Postpartum

Journal of Midwifery &Women's Health, EarlyView.
Introduction Several anatomical and endocrine factors have been linked to breastfeeding difficulties, yet there is limited evidence for their prevalence and associated postpartum breastfeeding outcomes. Knowledge of the prevalence and impact of nonmodifiable lactation risk factors can inform clinical care.
Sharon L. Perrella, Stuart A. Prosser, Philip Vlaskovsky, Donna T. Geddes   +3 more
wiley   +1 more source

Systemic Disease Associations of Oral Lichenoid Disease: A Retrospective Case–Control Study

Oral Diseases, EarlyView.
ABSTRACT Objective To analyze the association between oral lichen planus (OLP), oral lichenoid lesions (OLL), and other comorbidities. Material and Methods A case–control study of 205 OLP, 96 OLL patients, and 301 age‐ and sex‐matched controls from Kuopio University Hospital was performed.
Mari Vehviläinen, Tuomas Selander, Tuula Salo, Maria Siponen   +3 more
wiley   +1 more source