Results 41 to 50 of about 36,523 (215)

Benefits and Harms of Levothyroxine/L-Triiodothyronine Versus Levothyroxine Monotherapy for Adult Patients with Hypothyroidism: Systematic Review and Meta-Analysis

Thyroid, 2021
Background: Combined therapy with levothyroxine (LT4)/L-triiodothyronine (LT3) has garnered attention among clinicians and patients as a potential treatment alternative to LT4 monotherapy. The objective of this study was to compare the benefits and harms
J. M. Millán-Alanís, J. G. González‐González, A. Flores-Rodríguez, Naykky M Singh Ospina, S. Maraka, Pablo J Moreno-Peña, J. Brito, Camilo Gonzalez-Velazquez, R. Rodríguez‐Gutiérrez   +8 more
semanticscholar   +1 more source

The ages and TSH values of patients being prescribed levothyroxine

Therapeutic Advances in Endocrinology and Metabolism, 2020
Background: Levothyroxine is a commonly prescribed medication. Some data suggest that levothyroxine may be initiated for mild degrees of hypothyroidism and used without considering age-specific reference ranges or individual patient factors when ...
Jacqueline Jonklaas, Sameer DeSale
doaj   +1 more source

Design of the Optimal Trial of Combination Therapy

Frontiers in Endocrinology, 2020
Patients who take levothyroxine monotherapy to treat hypothyroidism frequently experience residual symptoms despite TSH testing at target levels. Trials have been conducted to evaluate the potential benefit of combination therapy with levothyroxine and ...
Anne R. Cappola
doaj   +1 more source

Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism

JAMA Network Open, 2021
Key Points Question Does levothyroxine treatment have an effect on the development of depressive symptoms in older adults with subclinical hypothyroidism?
L. Wildisen, M. Feller, C. Del Giovane, E. Moutzouri, R. D. Du Puy, S. Mooijaart, T. Collet, R. Poortvliet, P. Kearney, T. Quinn, S. Klöppel, D. Bauer, R. Peeters, R. Westendorp, D. Aujesky, J. Gussekloo, N. Rodondi   +16 more
semanticscholar   +1 more source

Factors influencing the levothyroxine dose in the hormone replacement therapy of primary hypothyroidism in adults

Reviews in Endocrine & Metabolic Disorders, 2021
Levothyroxine (LT4) is a safe, effective means of hormone replacement therapy for hypothyroidism. Here, we review the pharmaceutical, pathophysiological and behavioural factors influencing the absorption, distribution, metabolism and excretion of LT4 ...
P. Caron, S. Grunenwald, L. Persani, F. Borson‐Chazot, Rémy Leroy, L. Duntas   +5 more
semanticscholar   +1 more source

Levothyroxine Dosage Determination According to Body Mass Index (BMI) After Total Thyroidectomy

Erciyes Medical Journal, 2019
Objective: Currently, postoperative thyroid hormone replacement dosing is weight-based with adjustments and made following Thyroid Stimulating Hormone (TSH) values, which may lead to delayed achievement of euthyroidism and failure in achieving an ...
Hemmat Maghsoudi, Seyed Ehsan Mousavi Toomatari, Naser Agha Mohammadzade, Farzad Najafipour, Sara Akhavan Salamat, Seyed Babak Moosavi Toomatari, Afshin Gharekhani   +6 more
doaj   +1 more source

Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception

New England Journal of Medicine, 2019
Background Thyroid peroxidase antibodies are associated with an increased risk of miscarriage and preterm birth, even when thyroid function is normal. Small trials indicate that the use of levothyroxine could reduce the incidence of such adverse outcomes.
Rima K. DHILLON-SMITH, L. Middleton, Kirandeep K Sunner, V. Cheed, K. Baker, Samantha Farrell-Carver, R. Bender-Atik, R. Agrawal, K. Bhatia, E. Edi-Osagie, T. Ghobara, Pratima Gupta, D. Jurković, Y. Khalaf, M. MacLean, C. McCabe, Khashia Mulbagal, N. Nunes, C. Overton, S. Quenby, R. Rai, N. Raine-Fenning, L. Robinson, J. Ross, A. Sizer, R. Small, A. Tan, M. Underwood, M. Kilby, K. Boelaert, J. Daniels, S. Thangaratinam, Shiao Y Chan, A. Coomarasamy   +33 more
semanticscholar   +1 more source

Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials

Frontiers in Endocrinology, 2021
Background The cardiovascular effects of treating older adults with subclinical hypothyroidism (SCH) are uncertain. Although concerns have been raised regarding a potential increase in cardiovascular side effects from thyroid hormone replacement ...
Laurien E. Zijlstra, J. Jukema, R. Westendorp, R. D. Du Puy, R. Poortvliet, P. Kearney, L. O’Keeffe, O. Dekkers, M. Blum, N. Rodondi, T. Collet, T. Quinn, N. Sattar, D. Stott, S. Trompet, W. D. den Elzen, J. Gussekloo, S. Mooijaart   +17 more
semanticscholar   +1 more source

Congenital Hypothyroidism: Long-Term Growth and Intellectual Outcomes With a Lower Initial Levothyroxine Dose. [PDF]

Clin Endocrinol (Oxf)
ABSTRACT Objectives This study aims to review the long‐term outcome of congenital hypothyroidism (CH) and whether patient‐ or treatment‐related factors impact the outcomes, especially focusing on the initial Levothyroxine dose. Methods This is a retrospective, cross‐sectional study of the children diagnosed with CH who received Levothyroxine at Ajou ...
Park JH, Oh JH, Cho MH, Shim YS, Lee HS.
europepmc   +2 more sources

Levothyroxine Treatment and the Risk of Cardiac Arrhythmias – Focus on the Patient Submitted to Thyroid Surgery

Frontiers in Endocrinology, 2021
Levothyroxine (LT4) is used to treat frequently encountered endocrinopathies such as thyroid diseases. It is regularly used in clinical (overt) hypothyroidism cases and subclinical (latent) hypothyroidism cases in the last decade. Suppressive LT4 therapy
Z. Gluvić, M. Obradović, Alan J. Stewart, M. Essack, Samantha J. Pitt, V. Samardzic, Sanja Soskić, T. Gojobori, E. Isenovic   +8 more
semanticscholar   +1 more source