Results 251 to 260 of about 1,731,278 (307)

Expression of mucins (MUC1, MUC2, MUC5AC, and MUC6) and type 1 Lewis antigens in cases with and withoutHelicobacter pyloricolonization in metaplastic glands of the human stomach

Journal of Pathology, 2002
Leonor David, Celso A Reis, Julia Costa   +2 more
exaly   +2 more sources

Synthesis of Dimeric Lewis A and Lewis B–Lewis A Tumor-Associated Carbohydrate Antigen Oligosaccharide Fragments

The Journal of Organic Chemistry, 2023
Despite the interesting potential of tumor-associated carbohydrate antigens (TACAs) dimLea and LebLea to develop anticancer immunotherapies, little research has been conducted on these antigens. In our quest to discover fragments of these TACAs that could be targeted for the development of anticancer therapeutics, we report the synthesis of eight tri ...
Jeffrey Davidson, Charles Gauthier-Signore, France-Isabelle Auzanneau   +2 more
openaire   +2 more sources

Synthesis of type 2 Lewis antigens via novel regioselective glycosylation of an orthogonally protected lactosamine diol derivative [PDF]

Carbohydrate Research, 2016
The novel and efficient synthesis of type 2 Lewis antigens is reported in this study. The rationally designed lactosamine-3, 2′-diol derivative with an orthogonal set of protecting groups is efficiently glycosylated with a benzyl protected 1-thio-l ...
Yuji Yamazaki, Shunsaku Kimura, Masashi Ohmae   +2 more
exaly   +2 more sources

The intrinsic conformation of a Lewis antigen: The Lewis × trisaccharide

Chemical Physics Letters, 2009
Abstract The conformation of the Lewis x antigen has been determined, free of environmental perturbation, at low temperature in the gas phase to reveal a global minimum energy structure lying below the rigid stacked conformations adopted in aqueous solution, in the crystalline hydrate or when bound to proteins. The result suggests that water plays a
Su, Z., Wagner, Bea, Cocinero, E. J., Ernst, Beat, Simons, J.   +4 more
openaire   +2 more sources

Molecular mechanisms of Lewis antigen expression

Legal Medicine, 2005
Lewis antigens comprise type 1 (Lewis a, Lewis b) and type 2 (Lewis X, Lewis Y) carbohydrates. Lewis X and Lewis Y are regarded as tumor-associated markers, and some of these antigens and their derivatives interact with selectins, mediating cell-to-cell adhesion.
Mikiko, Soejima, Yoshiro, Koda
openaire   +2 more sources

Lewis and Secretor Gene Effects on Lewis Antigen and Postnatal Development of Lewis Blood Type

Neonatology, 2001
Lewis (Le) and Secretor (Se) gene effects on postnatal change in Lewis antigens are described based on the quantitative analysis of Lewis antigens in blood. Genuine Lewis blood types were determined by Le and Se genotyping in DNA samples obtained from umbilical cord blood and infant blood.
S, Ameno, H, Kimura, K, Ameno, X, Zhang, H, Kinoshita, T, Kubota, I, Ijiri   +6 more
openaire   +2 more sources

Lipopolysaccharide Lewis Antigens

2014
As determined by serological techniques, the O-antigen of lipopolysaccharide (LPS) of more than 80% of Helicobacter pylori strains tested worldwide express Lewis blood group antigens. Several host lectins are known to interact with host Lewis antigens; the same lectins may interact with H. pylori Lewis antigens.
Appelmelk, Ben J., Vandenbroucke-Grauls, Christina M. J. E.   +1 more
openaire   +2 more sources

The routine use of soluble Lewis antigens in the identification of Lewis system antibodies

Transfusion, 1993
Approximately 3 percent of the blood samples tested at the authors' laboratory have contained unexpected red cell (RBC) antibodies, of which about one‐third have been anti‐Le(a) or anti‐Le(b). Although these antibodies are usually clinically insignificant, considerable workload was expended in their identification.
I A, Shulman, R, Nakayama
openaire   +2 more sources

Lewis antigen alterations in gastric cancer precursors

Gastroenterology, 1992
To explore the dynamics of the progressive loss of cell differentiation observed in the gastric precancerous process, the abnormal expression of Lea antigen in the gastric epithelium was investigated. Gastric biopsy specimens of 122 subjects with Le(a-b+) phenotype who had intestinal metaplasia of the gastric mucosa were studied.
J, Torrado, P, Correa, B, Ruiz, P, Bernardi, D, Zavala, J, Bara   +5 more
openaire   +2 more sources

Expression of Lewis Antigenic Determinants in Colorectal Adenocarcinomas

Experimental Cell Biology, 2008
Expression of type 1 and type 2 chain Lewis antigens was studied in 32 rectal adenocarcinoma specimens; the results were correlated with the patients’ Lewis phenotype and secretor status. In addition, the pattern of expression of these antigens was analyzed in adjacent and distant normal mucosa.
E, Blasco, J, Torrado, A, Cosme, E, Alvarez, A, Zugasti, A, Gutierrez-Hoyos, J I, Arenas   +6 more
openaire   +2 more sources