Results 101 to 110 of about 18,410 (222)

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, Volume 13, Issue 33, 15 June 2026.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, Volume 13, Issue 35, 24 June 2026.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, Volume 13, Issue 35, 24 June 2026.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

Review: phenotyping for Lewis and secretor histo-blood group antigens [PDF]

Immunohematology, 1996
openaire   +2 more sources

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, Volume 13, Issue 36, 29 June 2026.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Relationships Among Maternal Epstein–Barr Virus Antibodies, COVID‐19, and Stress in Mothers up to 1‐Year Postpartum

American Journal of Human Biology, Volume 38, Issue 6, June 2026.
ABSTRACT Objectives Both psychosocial stress and current infection can increase the likelihood of reactivation of latent Epstein–Barr virus (EBV). Pregnancy and infection with SARS‐CoV‐2 can be stressful and modulate immune function. However, it is unknown how SARS‐CoV‐2 infection and stress further interact among postpartum women to affect EBV antigen
Emma Anastasi, Delaney J. Glass, Tiffany D. Pan, Eleanor Brindle, Beatrice Caffe, Caroline B. Smith, Amanda E. Kunkle, Maia A. Kent, Alexandra D. Navarrete, Christina D. W. Pace, Dan T. A. Eisenberg, Ryan M. Pace, Janet E. Williams, Sylvia H. Ley, Celestina Barbosa‐Leiker, Mark A. McGuire, Michelle K. McGuire, Courtney L. Meehan, Melanie A. Martin   +18 more
wiley   +1 more source

Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Nicole Rychlik, Kay Jüngling, Sven G. Meuth, Thomas Budde, Marta Méndez‐Couz   +4 more
wiley   +1 more source

Blood-group-related antigen Lewis(x) and Lewis(y) in the differential diagnosis of cholangiocarcinoma and hepatocellular carcinoma.

Archives of pathology & laboratory medicine, 1989
Distribution of Lewis(x) (Le(x)) and Lewis(y) (Le(y)) blood-group antigens was studied in nine formaldehyde-fixed, paraffin-embedded cholangiocarcinomas (CCs), 26 hepatocellular carcinomas (HCCs), and eight normal livers. All CCs, with one exception, expressed both Le(x) and Le(y) antigens on few or many cells. In HCCs Lex was expressed infrequently (8%
R, Jovanovic, J, Jagirdar, S N, Thung, F, Paronetto   +3 more
openaire   +1 more source

Multi‐omics analysis identifies a major histocompatibility complex class II‐associated antigen‐presenting cancer‐associated fibroblast‐like state linked to the nuclear factor erythroid 2‐related factor 2‐karyopherin subunit beta 1 axis in nonsmall cell lung cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
NSCLC contains an MHC‐II‐associated antigen‐presenting CAF‐like (apCAF‐like) state regulated by the NRF2‐KPNB1 axis. NRF2/KPNB1 signaling suppresses CIITA‐dependent antigen presentation and T‐cell activation, whereas inhibition of this pathway enhances antitumor immunity and improves responsiveness to anti‐PD‐1 therapy.
Fei Zheng, Ruoying Deng, Ran Hou, Lei Hong, Yanzhi Cui, Yibing Liu   +5 more
wiley   +1 more source