Results 51 to 60 of about 11,952,476 (292)

T-SP1: a novel serine protease-like protein predominantly expressed in testis [PDF]

, 2008
Here, we describe a novel member in the group of membrane-anchored chymotrypsin (S1)-like serine proteases, namely testis serine protease 1 (T-SP1), as it is principally expressed in testis tissue.
Geissler, Claudia, Jochum, Marianne, Naegler, Dorit K., Nerlich, Andreas, Neth, Peter, Profanter, Birgit, Sommerhoff, Christian P.   +6 more
core   +1 more source

Immunohistochemical detection of macrophage migration inhibitory factor in fetal and adult bovine epididymis: Release by the apocrine secretion mode? [PDF]

, 2006
Originally defined as a lymphokine inhibiting the random migration of macrophages, the macrophage migration inhibitory factor (MIF) is an important mediator of the host response to infection.
Agarwal A., Agrawal Y., Aumuller G., Bacher M., Bacher M., Bernhagen J., Bloom B.R., Bove S.E., Bronson R.A., Calandra T., Calandra T., Calandra T., Calne R.Y., Choufani G., Cooper T.G., Cropp C.S., David J.R., Eickhoff R., Eickhoff R., F. Sinowatz, Frenette G., Frenette G., Frenette G., G. Hoffbauer, G. Jennemann, Goyal H.O., H. Kaltner, H.-J. Gabius, Hoffer A.P., Howards S.S., Hudson J.D., J. Seitz, Kaltner H., Kaunisto K., Kirchhoff C., Kirchhoff C., Kleemann R., Legendre H., M.-P. Schüring, Manin M., Meinertz H., Meinhardt A., Meinhardt A., R. Eickhoff, Rosengren E., Seitz J., Steinhoff M., Sullivan R., Sun H.W., Suzuki M., Wada S., Wada S., Waeber G., Weiser W.Y., Wilhelm B., Zeng F.Y., Zeng F.Y., Zeng F.Y.   +57 more
core   +1 more source

Short-term stimulatory effect of Sertoli cell conditioned medium on Leydig cell steroidogenesis is not mediated by inhibin [PDF]

, 1990
Addition of concentrated rat Sertoli cell conditioned medium (rSCCM) to isolated Leydig cells from immature rats stimulated steroid production more than 13-fold within 4h. LH-stimulated steroidogenesis was not enhanced by addition of rSCCM.
Grootenhuis, A.J. (Arijan), Hoogerbrugge, J.W. (Jos), Jong, F.H. (Frank) de, Melsert, R. (R.), Rommerts, F.F.G. (Focko), Timmerman, M.A. (Marianna)   +5 more
core   +5 more sources

scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells

Cells, 2020
In December 2019, a novel coronavirus (SARS-CoV-2) was identified in COVID-19 patients in Wuhan, Hubei Province, China. SARS-CoV-2 shares both high sequence similarity and the use of the same cell entry receptor, angiotensin-converting enzyme 2 (ACE2 ...
Zhengpin Wang, Xiaojiang Xu
semanticscholar   +1 more source

Simultaneous Sertoli Cell-Only Syndrome and Leydig Cell Tumor in a Patient with Azoospermia: A Rare Case Report

Case Reports in Oncology, 2022
Testicular cancers comprise 1–1.5% of entire cancers in men, and sex cord-stromal tumors include 5% of testicular cancers. This study aims to report a simultaneous Sertoli cell-only syndrome and Leydig cell tumor in the same patient.
Rawa Bapir, Rawezh Q. Salih, Karzan M. Salih, Bana Shabur, Abdulwahid M. Salih, Fahmi H. Kakamad, Hiwa O. Abdullah, Fattah H. Fattah, Shvan H. Mohammed   +8 more
doaj   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

Relationship of transcriptional markers to Leydig cell number in the mouse testis.

PLoS ONE, 2019
ObjectivesThe current study aims to identify markers that would reflect the number of Leydig cells present in the testis, to help determine whether labour-intensive methods such as stereology are necessary.
Diane Rebourcet, Ana Monteiro, Lyndsey Cruickshanks, Nathan Jeffery, Sarah Smith, Laura Milne, Peter J O'Shaughnessy, Lee B Smith   +7 more
doaj   +1 more source

Bone morphogenetic protein 4 inhibits rat stem/progenitor Leydig cell development and regeneration via SMAD-dependent and SMAD-independent signaling

Cell Death and Disease, 2022
Bone morphogenetic protein 4 (BMP4) is an important member of the transforming growth factor-β superfamily. BMP4 is expressed in the Leydig cell lineage. We hypothesized that BMP4 might regulate the development of stem/progenitor Leydig cells.
Xiaoheng Li, Yinghui Fang, Lanlan Chen, Hehua Quan, Yiyan Wang, Ren-Shan Ge   +5 more
doaj   +1 more source

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, EarlyView.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

Essential roles of COUP-TFII in Leydig cell differentiation and male fertility. [PDF]

PLoS ONE, 2008
Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII; also known as NR2F2), is an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily.
Jun Qin, Ming-Jer Tsai, Sophia Y Tsai
doaj   +1 more source