The Libyan jird (Meriones libycus, 1823) is a wild desert rodent that is a seasonal breeder species adapted to breed when the environmental conditions can satisfy the energy and hydrous requirements of pregnant and nursing females to ensure that births ...
Radia Boufermes +3 more
doaj +1 more source
Is polycystic ovary syndrome a sexual conflict? A review [PDF]
Several studies have attempted to explain the high overall prevalence of polycystic ovary syndrome among women worldwide (about 4-10%) despite its link to subfertile phenotypes. For this reason, it is considered an evolutionary paradox.
BRIGANTE, Giulia +2 more
core +1 more source
Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene
Testotoxicosis is a rare disorder which presents as isosexual peripheral precocious puberty in males. Despite the pattern of autosomal dominant inheritance, sporadic cases also may occur. Due to activating mutation in luteinizing hormone (LH))/choriogonadotropin receptor (LHCGR) gene, early virilization and advancement in bone age are common with ...
Bahar Özcabı +7 more
openalex +3 more sources
Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis [PDF]
Despite the well-established tumor suppressive role of TGFβ proteins, depletion of key TGFβ signaling components in the mouse ovary does not induce a growth advantage.
Bartholin, Laurent +5 more
core +1 more source
The Role of the Brain in the Pathogenesis and Physiology of Polycystic Ovary Syndrome (PCOS). [PDF]
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting at least 10% of women of reproductive age. PCOS is typically characterized by the presence of at least two of the three cardinal features of hyperandrogenemia (high ...
Coutinho, Eulalia A +1 more
core +1 more source
Hinge region mediates signal transmission of luteinizing hormone and chorionic gonadotropin receptor
Luteinizing hormone-choriogonadotropin receptor (LHCGR), a class A G protein-coupled receptor (GPCR), plays a pivotal role in the maturation of reproductive organs and embryonic development.
Xinheng He +7 more
doaj +1 more source
Sp1 regulates steroidogenic genes and LHCGR expression in primary human luteinized granulosa cells [PDF]
Luteinizing hormone and human chorionic gonadotropin (hCG) bind to the luteinizing hormone/chorionic gonadotropin receptor (LHCGR). LHCGR is required to maintain corpus luteum function but the mechanisms involved in the regulation of LHCGR in human luteal cells remain incompletely understood.
Scott, Convissar +5 more
openaire +2 more sources
Background Upon binding luteinizing hormone in the ovary, the luteinizing hormone/choriogonadotropin receptor (LHCGR) is necessary for follicular maturation and ovulation, as well as luteal function.
Yu Yong +6 more
doaj +1 more source
Molecular determinants of a competent bovine corpus luteum: first vs final wave dominant follicles [PDF]
Reproductive management in cattle requires the synchrony of follicle development and oestrus before insemination. However, ovulation of follicles that have not undergone normal physiological maturation can lead to suboptimal luteal function.
B K Campbell +11 more
core +1 more source
The utility of circulating LHCGR as a predictor of Down's syndrome in early pregnancy [PDF]
Previous studies showed that soluble LHCGR/hCG-sLHCGR concentrations in serum or plasma combined with PAPP-A and free βhCG significantly increased the sensitivity of Down's syndrome screen at early pregnancy without altering the false positive rate. The goal of the present study was to further examine the role of sLHCGR forms as combinatorial markers ...
Chambers, Anne E +11 more
openaire +2 more sources

