Results 11 to 20 of about 4,394,525 (348)
Annual Review of Biochemistry, 2018 The discovery of organic ligands that bind specifically to proteins is a central problem in chemistry, biology and biomedical sciences. The encoding of individual organic molecules with distinctive DNA tags, serving as amplifiable identification barcodes,
Dario Neri, Richard A Lerner
exaly +2 more sources
Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules
Nature Chemistry, 2018 DNA-encoded libraries have emerged as a widely used resource for the discovery of bioactive small molecules, and offer substantial advantages compared with conventional small-molecule libraries.
Dmitry L Usanov +2 more
exaly +2 more sources
International Journal of Innovative Science and Research Technology, 2023 This study determines the Accessibility, usability and satisfaction of library users in the hybrid resources and services of academic libraries in Albay province. The methodology used in this research was descriptive-correlational technique. As result in
Abigail B. Sadueste, M. L. Masalinto
semanticscholar +1 more source
Synthon-based ligand discovery in virtual libraries of over 11 billion compounds
Nature, 2021 Structure-based virtual ligand screening is emerging as a key paradigm for early drug discovery owing to the availability of high-resolution target structures1–4 and ultra-large libraries of virtual compounds5,6.
Arman A. Sadybekov +19 more
semanticscholar +1 more source
KULA, 2022 Migrating archival description from paper-based finding aids to structured online data reconfigures the dynamics of archival representation and interactions.
Daniela Ansovini +5 more
doaj +1 more source
Heritage conservation in war and post-war conditions during the 1990s
Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2023 Purpose. The aim of the paper is to describe the activities undertaken by Dubrovnik Libraries during and after the Croatian War of Independence to preserve their heritage collections. The intention is also to present plans for possible future challenges
Paula Raguz, Tina Di Reda, Damjan Polić
doaj +1 more source
Improved vectors and genome-wide libraries for CRISPR screening
Nature Methods, 2014 Genome-wide, targeted loss-of-function pooled screens using the CRISPR (clustered regularly interspaced short palindrome repeats)–associated nuclease Cas9 in human and mouse cells provide an alternative screening system to RNA interference (RNAi) and ...
Neville E. Sanjana +2 more
semanticscholar +1 more source
Sixteen Million Pages and Counting: Laurie Gemmill on the LYRASIS Mass Digitization Collaborative
Virginia Libraries, 2012 Virginia Libraries
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Journal of Librarianship and Scholarly Communication, 2023 Introduction: This mixed-method study analyzes the self-archiving behaviors and underlying motivations of researchers at an institution very recently recategorized by the Carnegie Classification system from “Doctoral– High Research Activity (R2)” to ...
Jack Maness +3 more
doaj +2 more sources