Results 51 to 60 of about 4,127,534 (292)
Evidence Based Library and Information Practice, 2015 No abstract.
Jessica Thorlakson +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
VLA Paraprofessional Forum Report: Communication 2012
Virginia Libraries, 2012 Virginia Libraries
doaj
Flipping it online: re-imagining teaching searching for knowledge syntheses
Journal of the Canadian Health Libraries Association, 2021 Introduction: This program description outlines our approach to re-developing our 3-part series for graduate students on comprehensive searching for knowledge syntheses from in-person to online delivery using a flipped classroom model. The re-development
Kaitlin Fuller +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Libraries and Founders of Libraries [PDF]
Notes and Queries, 1965 This comprehensive volume, first published in 1864, covers the history of libraries from classical times to the nineteenth century, principally in England but also further afield. The author was an influential figure in the founding of municipal libraries in nineteenth-century Britain and regarded access to good libraries as crucial to education and ...
+4 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Literacy and Sustainability in Virginia’s Libraries: 2011 VLA Annual Conference
Virginia Libraries, 2012 Virginia Libraries
doaj
Public libraries and social exclusion: the historical legacy [PDF]
, 2000 This paper reviews the history of attempts made by public libraries to develop services for the “disadvantaged” and socially excluded. It analyses in particular three models: the Victorian “working class” public library; the “welfare state” public ...
Muddiman, Dave
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source