Results 71 to 80 of about 4,420,672 (386)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Phage Display Libraries for Antibody Therapeutic Discovery and Development
Antibodies, 2019 Phage display technology has played a key role in the remarkable progress of discovering and optimizing antibodies for diverse applications, particularly antibody-based drugs.
J. C. Almagro +3 more
semanticscholar +1 more source
Special Libraries, January 1921 [PDF]
, 1920 Volume 12, Issue 1https://scholarworks.sjsu.edu/sla_sl_1921/1000/thumbnail ...
Special Libraries Association
core +3 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Virginia Library Association 2012 Annual Conference
Virginia Libraries, 2013 Virginia Libraries Staff
doaj
Genome-wide SWAp-tag yeast libraries for proteome exploration
Nature Methods, 2018 Yeast libraries revolutionized the systematic study of cell biology. To extensively increase the number of such libraries, we used our previously devised SWAp-Tag (SWAT) approach to construct a genome-wide library of ~5,500 strains carrying the SWAT ...
Uri Weill +24 more
semanticscholar +1 more source
Special Libraries, January 1946 [PDF]
, 1945 Volume 37, Issue 1https://scholarworks.sjsu.edu/sla_sl_1946/1000/thumbnail ...
Special Libraries Association
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A Universe of Knowledge in One Small Space: 2013 VLA Annual Conference
Virginia Libraries, 2013 Virginia Libraries Staff
doaj