Results 141 to 150 of about 823,276 (296)

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran   +13 more
wiley   +1 more source

Development in theoretical study and practice of library legislation in China

open access: yes, 2008
One of the most outstanding characteristics of library legislation in China is that theoretical research and legislative practice are mutually reinforcing, making important issues and basic rules and regulations closely associated with legislation and ...
LI Guoxin   +4 more
core  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Disciplinary Interflow of Library and Information Science in Taiwan

open access: yes, 2010
本研究以「臺灣人文學引文索引資料庫」收錄之1996-2002圖書資訊學期刊論文為研究對象,探討台灣近年之圖書資訊學跨學科研究的特性。研究結果顯示,圖書資訊學研究者最常與「社會科學」及「工程技術」類的研究者進行合作研究,從事「圖書資訊技術」和「讀者服務」的研究者,比較常與其他學科的研究者進行合作研究。至於引用之行為,圖書資訊學研究者最常引用「社會科學」、「攻城技術」和「歷史」類的文獻資料,其中又以論文出版前五至十年之中文圖書為主。跨學科引用指數顯示「行政與管理」這類的研究主題跨學科引用程度是最高的 ...
Chen, Kuang-hua; Liang, Chiung-fang   +1 more
core  

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang   +4 more
wiley   +1 more source

Information resources management of T.I.S.S library

open access: yes, 2003
Gives step-by-step information resource development, including hardware and software in T.I.S.S. Library. With the changing concept of document and user’s demand, library needs to create indigenous databases and explore external online databases.
Subramanian, Shyamala   +2 more
core  

Political Reformation and its Impact on Library And Information Science Education And Practice: A Case Study Of Indonesia During And Post-President-Soeharto Administration [PDF]

open access: yes, 2006
The author discusses library and information science education before and after 1998, the year President Soeharto stepped down. Before 1998, the government centralized policy making.
L Sulistyo-Basuki   +2 more
core  

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi   +8 more
wiley   +1 more source

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