Results 51 to 60 of about 570,239 (252)

هزینه- سودمندی کتاب‌های فارسی مربوط به رشته‌ی کتابداری و اطلاع‌رسانی در دانشگاه علوم پزشکی جندی شاپور اهواز

open access: yesمدیریت اطلاعات سلامت, 2012
مقدمه: ارزیابی‌های کمی از معیارهای مناسب جهت تأیید یا رد انتخاب منابع اطلاعاتی کتابخانه‌ها به شمار می‌روند. از طریق این ارزیابی‌ها می‌توان تناسب بین منابع انتخاب شده با نیازهای جامعه‌ی استفاده کننده‌ی کتابخانه را با توجه به میزان استفاده‌ی آنان از منابع ...
Firoozeh Zare Farashbandi   +3 more
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Efficiency and productivity of county-level CDCs in Qingdao municipal, China: a retrospective study based on 6 years of panel data

open access: yesBMC Health Services Research
Background County-level Centers for Disease Control and Prevention (CDCs) are the foundational units of China’s public health system. The COVID-19 pandemic has highlighted the shortcomings of the system, making it urgent to strengthen the functions of ...
Chongyi Wang   +7 more
doaj   +1 more source

Scientific Products of Authors at Hamadan University of Medical Sciences in Web of Science (WOS) and Scopus Databases

open access: yesمدیریت اطلاعات سلامت, 2012
• Introduction: One of the common methods for scientific activity assessment is scientometrics. It has been made possible with citation databases like Web of Science (WOS) and Scopus.
Ali Valinejadi   +4 more
doaj  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

Information Seeking Skills in Online Databases of Iranian National Medical Digital Library: A Study among Residents of Isfahan University of Medical Sciences

open access: yesمدیریت اطلاعات سلامت, 2013
Introduction: Information seeking skills has an important role in independent searching and enables one to have a strong research. The aim of this study was to investigate information seeking skills among the residents of Isfahan University of Medical ...
Mohammadreza Hashemian   +2 more
doaj  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

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