Results 61 to 70 of about 513,578 (251)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Efficiency and productivity of county-level CDCs in Qingdao municipal, China: a retrospective study based on 6 years of panel data

BMC Health Services Research
Background County-level Centers for Disease Control and Prevention (CDCs) are the foundational units of China’s public health system. The COVID-19 pandemic has highlighted the shortcomings of the system, making it urgent to strengthen the functions of ...
Chongyi Wang, Kunzheng Lyu, Dan Lin, Mile Lin, Ying Zhang, Ayan Mao, Yujie Yang, Wuqi Qiu   +7 more
doaj   +1 more source

Use of the Expertise and Experience of Medical Librarians to Evaluate the Scientific Background of the Volunteers of the PhD. of the Ministry of Health and Medical Education: Describing an Experience

مدیریت اطلاعات سلامت, 2018
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Mohammadreza Soleymani, Shahin Mojiri, Hasan Ashrafi-Rizi   +2 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Scientific Products of Authors at Hamadan University of Medical Sciences in Web of Science (WOS) and Scopus Databases

مدیریت اطلاعات سلامت, 2012
• Introduction: One of the common methods for scientific activity assessment is scientometrics. It has been made possible with citation databases like Web of Science (WOS) and Scopus.
Ali Valinejadi, Hossein Vakili Mofrad, Mohammad Reza Amiri, Hafez Mohammadhasanzadeh, Hamid Bouraghi   +4 more
doaj  

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Information Seeking Skills in Online Databases of Iranian National Medical Digital Library: A Study among Residents of Isfahan University of Medical Sciences

مدیریت اطلاعات سلامت, 2013
Introduction: Information seeking skills has an important role in independent searching and enables one to have a strong research. The aim of this study was to investigate information seeking skills among the residents of Isfahan University of Medical ...
Mohammadreza Hashemian, Mohammad Janatikia, Alireza Hashemian   +2 more
doaj