Results 31 to 40 of about 850,808 (265)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Data-Science Approach for Creation of a Comprehensive Model to Assess the Impact of Mobile Technologies on Humans

Applied Sciences, 2023
Mobile technologies are an essential part of people’s everyday lives since they are utilized for a variety of purposes, such as communication, entertainment, commerce, and education.
Magdalena Garvanova, Ivan Garvanov, Vladimir Jotsov, Abdul Razaque, Bandar Alotaibi, Munif Alotaibi, Daniela Borissova   +6 more
doaj   +1 more source

Study about Library and Information Center's Image of Library and Information Science Students as Workplace

Journal of the Korean Society for Library and Information Science, 2016
소비자에게 형성된 심상 분석을 통해 마케팅 전략을 수립하는데 주로 활용되고 있는 포지셔닝(Positioning) 기법은 공공시설, 기업, 대학이 공중에게 주는 이미지 분석을 비롯해 다양한 영역에서 활용되고 있다. 본 연구는 문헌정보학과 학생이 직장으로서 도서관 · 정보센터에 대하여 가지고 있는 이미지를 포지셔닝 기법을 통하여 분석하였다. 분석 결과, 학생들은 공공, 대학, 학교, 국가도서관을 유사한 이미지의 직장으로 인식하는 반면, 포털과 전문도서관은 이들과는 이질적인 진출처로 인식하고 있었으며, 직무에 있어서는 이용자봉사업무와 기술업무, 문화프로그램 업무를 각각 상이한 직무 군집으로 인식하고 있는 것으로 나타났다.
Jane Cho, Jiwon Lee
openaire   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Information visualisation and library data: A case study of Public Library of Veria, Greece

ELPUB 2019 23d International Conference on Electronic Publishing, 2019
This paper comprises an attempt to create information visualizations for the Public Library of Veria city, Greece based on library data. Specifically, it is a formative study about the use of a visualization tool for analysing library data. The goal of this study is to make suggestions for the presentation of the public library’s data in order to be ...
Gkioulekas, Panagiotis, Polydoratou, Panayiota   +1 more
openaire   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Geography Education in a Collaborative Virtual Environment: A Qualitative Study on Geography Teachers

ISPRS International Journal of Geo-Information, 2022
The presented study aspires to utilize the gradually validated immense potential of collaborative immersive virtual environments (CIVEs) in higher education when designing and conducting geography lessons. These particular lessons focused on hypsography.
Kateřina Jochecová, Michal Černý, Zdeněk Stachoň, Hana Švedová, Natálie Káčová, Jiří Chmelík, Vojtěch Brůža, Ondřej Kvarda, Pavel Ugwitz, Alžběta Šašinková, Nicola Catherine Fořtová, Čeněk Šašinka   +11 more
doaj   +1 more source

Practicums as part of study programmes in library and information studies

Andragoška spoznanja, 2016
In Library and Information Science (LIS) courses, practicums serve as a specific bond between theory on the one hand and practical work and the profession on the other. In seeking to prepare graduates for the profession and for professional work, LIS programmes use practicums as a model to enhance the library school curriculum.
Južnič, Primož, Pymm, Bob
openaire   +4 more sources