Results 41 to 50 of about 850,808 (265)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

The Content Analysis and Application Problem of the Preservation Policy in Archives

open access: yesTūzī yǔ dàng’àn xuékān, 2016
Archival repositories have to provide an appropriate storage environment and take effective measures of preservation and conservation, and thus a preservation policy, assisting to settle down all of these works, is indispensable.
Chiao-Min Lin, Pei-Shan Li
doaj   +1 more source

E-hand News

open access: yesTūzī yǔ dàng’àn xuékān, 2022
This research collects all newspaper titles published in the United Daily News from 2019 to 2020. Through word segmentation, part-of-speech tagging, sentiment analysis, NRC Emotion Lexicon and other technologies, supplemented by website development, it ...
Hui-Ru Chen, Chung-Ming Lo
doaj   +1 more source

School libraries, political information and information literacy provision: [PDF]

open access: yesJournal of Information Literacy, 2016
This paper presents the findings of research which explored Scottish school libraries’ information provision and information literacy (IL) support in the run-up to two major political events: the 2014 Scottish Independence Referendum (SIR) and the 2015 General UK Parliamentary Election (GE). To do this, the project identified, through an online survey,
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Greek and Spanish Undergraduate Perspectives on Academic Librarianship, Within and Beyond Library Science Curricula

open access: yesBilgi Dünyası, 2019
Library and information science undergraduate programs’ adequacy to prepare new information professionals has become the topic of an ongoing debate, with opposing arguments about curricular structure and focus.
Stavroula Sant-Geronikolou   +2 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Establishment of an E-Portfolio System for Professional Development: A Case Study of Library Association of the Republic of China (Taiwan)

open access: yesTūzī yǔ dàng’àn xuékān, 2015
In recent years, there have been many e-Portfolio systems in Taiwan implemented for students' learning in universities yet rarely for professional development.
Meng-Yi Lin, Hao-Ren Ke
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

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