Results 91 to 100 of about 24,850,540 (303)
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Pakistan Journal of Information Management & Libraries, 2008 This paper traces the history of the initiative that led to the formation of the Pakistan Library Association and deals with the difficulties it faced in its functioning during the first few years of its life. It uses primary documents dealing with this
Mumtaz A. Anwar
doaj
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Minutes of Meeting: Management of Library Associations Section, Monday, 25 November, 2024
The last Management of Library Associations Section (MLAS) Standing Committee Meeting for the year 2024 was held on 25 November, 2024 via zoom. The meeting was chaired by Loida and was well attended by 17 MLAS Standing Committee Members, NPSIG and ...
IFLA Management of Library Associations Section
core
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Meeting Minutes: Management of Library Associations Section Standing Committee, 16 September 2024
Meeting Minutes of the IFLA Management of Library Associations Section Standing Committee, held on Monday 16 September ...
IFLA Management of Library Associations Section
core
Minutes of Meeting: Management of Library Associations and Institutions Section, 23 April 2024
This is the 3rd MLAS Standing Committee Meeting for the year 2024. Sharon Memis, IFLA Secretary General was a guest at this meeting and gave an update on IFLA activities. Among the updates were fuller minutes from the IFLA GB; IFLA General Assembly 2024;
IFLA Management of Library Associations Section Standing Committee
core +1 more source