Results 281 to 290 of about 295,880 (349)

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

esMPRA: an easy-to-use systematic pipeline for MPRA experiment quality control and data analysis. [PDF]

Bioinformatics
Li J, Zhang P, Xi X, Wang X.
europepmc   +1 more source

Contribution of Latest Technologies in Library Automation

Shiv Kumar, Pankaj Kumar Bharti, Vijay K. Yadav   +2 more
openalex   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Lifecycles of Cochrane Systematic Reviews (2003-2024): A Bibliographic Study. [PDF]

Cochrane Evid Synth Methods
Li S, Wu C, Zhang Z, Xiao M, Murad MH, Lin L.   +5 more
europepmc   +1 more source

Automation of libraries and information units: reviewing criteria and characteristics for the best investment [PDF]

Miguel Romeu Amorim Neto, Samantha Eunice de Miranda Marques Pontes   +1 more
openalex  

Quantifying Additive Manufacturing Vapor Plumes Using Laser‐Induced Breakdown Spectroscopy, Synchrotron X‐Ray Radiography and Simulations

Advanced Science, EarlyView.
This study presents a novel in situ laser‐induced breakdown spectroscopy system for monitoring metal vapors produced by the intense laser‐metal interactions in laser powder bed fusion additive manufacturing and laser welding. The insights from this new technique reveal changes in alloy compositions and provide the first in situ validation of multi ...
Anna C. M. Getley, Samy Hocine, Junji Shinjo, Chinnapat Panwisawas, Marta Majkut, Alexander Rack, Peter D. Lee, Michael Towrie, Chu Lun Alex Leung   +8 more
wiley   +1 more source

PseudoChecker2 and PseudoViz: automation and visualization of gene loss in the Genome Era. [PDF]

Bioinform Adv
Resende-Pinto R, Ruivo R, Stiller J, Fonseca R, Castro LFC.   +4 more
europepmc   +1 more source

Automated Platforms in <i>C. elegans</i> Research: Integration of Microfluidics, Robotics, and Artificial Intelligence. [PDF]

Micromachines (Basel)
Mahbub TB, Safaeian P, Sohrabi S.
europepmc   +1 more source

Rapid Nanopore Sequencing of Positive Blood Cultures Using Automated Benzyl-Alcohol Extraction Improves Time-Critical Sepsis Management. [PDF]

Antibiotics (Basel)
Tai CS, Chung HY, Lin TH, Chang CK, Perng CL, Hsieh PS, Shang HS, Jian MJ.   +7 more
europepmc   +1 more source