Results 21 to 30 of about 29,768 (267)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The introduction of library automation in the National and University Library and Slovene public libraries

Knjižnica, 2005
In a series of articles on library automation, this is the first one describing and analyzing the introduction of library automation in the National and University Library in Ljubljana and in other Slovene public libraries from the outset to 1977.
Stanislav Bahor
doaj   +1 more source

Automation of hybridization and capture based next generation sequencing library preparation requires reduction of on-deck bead binding and heated wash temperatures

SLAS Technology, 2022
Capture-based library preparation for next generation sequencing (NGS) offers a balance between sequencing depth and bioinformatics cost of analysis.
Eric Zimmerman Zuckerman, Joseph A. Thompson, Amber R. Schneider, Michael B. Campion, Jennifer J Johns, Theodore J. Stier, Lisa M. Peterson, Amanda M. Ward, Joseph H. Blommel, Rohan D. Gnanaolivu, Kimberly P. Lauer, Gopinath Sivasankaran, Jagadheshwar Balan, Surendra Dasari, Yuta Sakai, Cherisse A. Marcou, Gang Zheng, Kevin C. Halling, Wei Shen, David S. Viswanatha, Zhiyv Niu   +20 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Automation Based Library Management in Depok Public Library In The Context of Ritual Performance

Record and Library Journal, 2018
Library management using manual system is no longer adequate to handle the workload in the library routines, librarians must use application of library automation.
Rafiqa Maulidia, Laksmi Laksmi
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Assessment and Adoption of Cloud Computing among Academic Libraries in Philippines

University Library at a New Stage of Social Communications Development
Objective. Because cloud computing offers adaptable, scalable, and affordable technological solutions, it has profoundly changed academic librarianship.
E. D. MALABANAN
doaj   +1 more source

Transfer und Transformation

Bibliothek, 2021
Es werden wichtige Etappen der Bibliotheksentwicklung der letzten 50 Jahre angesprochen. Am Anfang stehen die Bibliothekspläne der 70er- und 80er-Jahre, die Grundlagen oder Forderungskataloge für den Ausbau und die Reorganisation des Bibliothekswesens ...
Mittler Elmar
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Digital Tools of the Academic Library: Automation of Publication Activity Monitoring

University Library at a New Stage of Social Communications Development
Objective. This publication studies the potential for using artificial intelligence and open APIs (Application Programming Interface) to automate publication activity monitoring. Methods.
O. A. SHEVCHUK, A. A. SALTYKOVA
doaj   +1 more source