Results 61 to 70 of about 2,463,396 (307)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

HELIN Consortium LORI Grant United States Online History_Digital Repository Sites [PDF]

open access: yes, 2014
Description of state online history,digital repository sites, repared by: Emily Cuellar and Thomas Evans, Rhode Island State Library, July ...

core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

History of Library Computerization

open access: yesInformation Technology and Libraries, 1970
The history of library computerization from its initiation in 1954 to 1970 is described. Approximately the first half of the period was devoted to computerization of user-oriented subject infotmation retrieval and the second half to library-oriented ...
Frederick G. Kilgour
doaj   +1 more source

Rare books as historical objects: a case study of the Elmer E. Rasmuson Library rare books collection [PDF]

open access: yes, 2016
Thesis (M.S.) University of Alaska Fairbanks, 2015Once upon a time all the books in the Arctic were rare books, incomparable treasures to the men and women who carried them around the world.
Korotkova, Ulyana Aleksandrovna   +1 more
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

University Scholar Series: Mary Pickering [PDF]

open access: yes, 2010
Auguste Comte: An Intellectual Biography On November 17, 2010 Mary Pickering spoke in the University Scholar Series hosted by Provost Gerry Selter at the Dr. Martin Luther King, Jr. Library.
Pickering, Mary
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Erich Meyerhoff, AHIP, FMLA, 1919–2015: a remembrance

open access: yesJournal of the Medical Library Association, 2017
None
Stephen J. Greenberg
doaj   +1 more source

State promotion of local public goods: The case of public libraries, 1880-1929 [PDF]

open access: yes, 2016
The public library movement of the late nineteenth and early twentieth centuries led to a significant expansion of library services across the United States.
Kevane, Michael J, Sundstrom, William A.
core   +1 more source

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